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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.11
- 수록면
- 871 - 879 (9page)
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Levels of maturation-promoting factor (MPF) in oocytes decline after vitrification, and this decline has been suggested as one of the main causes of low developmental competence resulting from cryoinjury. Here, we evaluated MPF activity in vitrified mouse eggs following treatment with caffeine, a known stimulator of MPF activity, and/or the proteasome inhibitor MG132. Collected MII oocytes were vitrified and divided into four groups: untreated, 10 mM caffeine (CA), 10 ?M MG132 (MG), and 10 mM caffeine +10 ?M MG132 (CA+MG). After warming, the MPF activity of oocytes and their blastocyst formation and implantation rates in the CA, MG, and CA+MG groups were much higher than those in the untreated group. However, the cell numbers in blastocysts did not differ among groups. Analysis of the effective-ness of caffeine and MG132 for improving somatic cell nuclear transfer (SCNT) technology using cryopreserved eggs showed that supplementation did not improve the blastocyst formation rate of cloned mouse eggs. These results suggest that maintaining MPF activity after cryopreservation may have a positive effect on further embryonic development, but is unable to fully overcome cryoinjury. Thus, intrinsic factors governing the developmental potential that diminish during oocyte cryopreservation should be explored.
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참고문헌 (27)
참고문헌 신청
Ariu, F. / 2014 / Effect of caffeine treatment before vitrification on MPF and MAPK activity and spontaneous parthenogenetic activation of in vitro matured ovine oocytes / Cryo Lett 35:530~536
Bernard, A. / 1996 / Cryopreservation of human oocytes: a review of current problems and perspectives / Hum. Reprod. Update 2:193~207
Soo Kyung Cha / 2011 / Effects of various combinations of cryoprotectants and cooling speed on the survival and further development of mouse oocytes after vitrification / Clinical and Experimental Reproductive Medicine 38(1):24~30
Chung, Y. G. / 2015 / Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells / Cell Stem Cell 17:758~766
Dupre, A. / 2002 / Mos is not required for the initiation of meiotic maturation in Xenopus oocytes / EMBO J 21:4026~4036
Bernard, A. / 1996 / Cryopreservation of human oocytes: a review of current problems and perspectives / Hum. Reprod. Update 2:193~207
Soo Kyung Cha / 2011 / Effects of various combinations of cryoprotectants and cooling speed on the survival and further development of mouse oocytes after vitrification / Clinical and Experimental Reproductive Medicine 38(1):24~30
Chung, Y. G. / 2015 / Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells / Cell Stem Cell 17:758~766
Dupre, A. / 2002 / Mos is not required for the initiation of meiotic maturation in Xenopus oocytes / EMBO J 21:4026~4036
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