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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 542 - 549 (8page)
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Cardiomyocyte apoptosis is initiated by various cellular insults and accumulated cardiomyocyte apoptosis leads to the pathogenesis of heart failure. Excessive reactive oxygen species (ROS) provoke apoptotic cascades. Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme that converts cellular ROS into harmless products. In this study, we demonstrate that MnSOD is down-regulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury. Enhanced expression of MnSOD attenuates cardiomyocyte apoptosis and myocardial infarction induced by I/R injury. Further, we show that miR-23a directly regulates the expression of MnSOD. miR-23a regulates cardiomyocyte apoptosis by suppressing the expression of MnSOD. Our study reveals a novel model regulating cardiomyocyte apoptosis which is composed of miR-23a and MnSOD. Our study provides a new method to tackling apoptosis related cardiac diseases.
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참고문헌 (39)
참고문헌 신청
Barringhaus, K. G. / 2009 / MicroRNAs : regulating a change of heart / Circulation 119:2217~2224
Bartel, D. P. / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Barwari, T. / 2016 / MicroRNAs in cardiovascular disease / J. Am. Coll.Cardiol 68:2577~2584
Candas, D. / 2014 / MnSOD in oxidative stress responsepotential regulation via mitochondrial protein influx / Antioxid. Redox Signal 20:1599~1617
Chen, Y. R. / 2014 / Cardiac mitochondria and reactive oxygen species generation / Circ. Res 114:524~537
Bartel, D. P. / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Barwari, T. / 2016 / MicroRNAs in cardiovascular disease / J. Am. Coll.Cardiol 68:2577~2584
Candas, D. / 2014 / MnSOD in oxidative stress responsepotential regulation via mitochondrial protein influx / Antioxid. Redox Signal 20:1599~1617
Chen, Y. R. / 2014 / Cardiac mitochondria and reactive oxygen species generation / Circ. Res 114:524~537
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