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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.5
- 수록면
- 315 - 321 (7page)
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The inositol polyphosphates are a group of mul-tifunctional signaling metabolites whose synthesis is catalyzed by a family of inositol kinases that are evolutionarily conserved from yeast to humans. Inositol polyphosphate multikinase (IPMK) was first identified as a subunit of the arginine-responsive transcription complex in budding yeast. In addition to its role in the production of inositol tetrakis- and pentakisphosphates (IP4 and IP5), IPMK also exhibits phosphatidylinositol 3-kinase (PI3-kinase) activity. Through its PI3-kinase activity, IPMK activates Akt/PKB and its downstream signaling pathways. IPMK also regulates several protein targets non-catalytically via protein-protein interactions. These non-catalytic targets include cytosolic signaling factors and transcription factors in the nucleus. In this review, we highlight the many known functions of mammalian IPMK in controlling cellular signaling networks and discuss future challenges related to clarifying the unknown roles IPMK plays in physiology and disease.
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참고문헌 (81)
참고문헌 신청
Ahmed, I. / 2015 / Huntington’s disease: Neural dysfunction linked to inositol polyphosphate multikinase / Proc. Natl. Acad. Sci. USA 112:9751~9756
Akira, S. / 2001 / Toll-like receptors : critical proteins linking innate and acquired immunity / Nat. Immunol 2:675~680
Alessi, D. R. / 2006 / LKB1-dependent signaling pathways / Annu. Rev. Biochem 75:137~163
Bang, S. / 2012 / AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase / Proc. Natl. Acad. Sci. USA 109:616~620
Bang, S. / 2014 / Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action / Mol. Endocrinol 28:1186~1193
Akira, S. / 2001 / Toll-like receptors : critical proteins linking innate and acquired immunity / Nat. Immunol 2:675~680
Alessi, D. R. / 2006 / LKB1-dependent signaling pathways / Annu. Rev. Biochem 75:137~163
Bang, S. / 2012 / AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase / Proc. Natl. Acad. Sci. USA 109:616~620
Bang, S. / 2014 / Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action / Mol. Endocrinol 28:1186~1193
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