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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 6 (6page)
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Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate ($5-IP_7$) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases, which both phosphorylate inositol hexakisphosphate ($IP_6$). In mammals, PP-IPs are implicated in diverse biological phenomena including cellular growth, vesicular trafficking, apoptosis, and metabolic homeostasis. Mechanistically, all the diverse actions of PP-IPs proceed in one of two ways: the PP-IPs modulate the activity of their target proteins either through allosteric binding or protein pyrophosphorylation. In this review, we highlight recent advances in our understanding of the pleiotropic functions of the mammalian PP-IPs and the metabolic enzymes that produce them. We also discuss some future challenges in the exploration of areas where PP-IPs play important but unknown roles in physiology and disease.
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참고문헌 (46)
참고문헌 신청
Albert C / 1997 / Biological variability in the atructures of diphosphoinositol polyphosphates in Dictyostelium Discoideum and mammalian cells / Biochem J. 327:553~560
Azevedo C / 2009 / Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release / Proc Natl Acad Sci USA 106:21161~21166
Azevedo C / 2006 / Extraction and analysis of soluble inositol polyphosphates from yeast / Nat Protoc 1:2416~2422
Barker CJ / 2004 / Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle / Biochem J. 380:465~473
Bhandari R / 2008 / Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis / Proc Natl Acad Sci USA 105:2349~2353
Azevedo C / 2009 / Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release / Proc Natl Acad Sci USA 106:21161~21166
Azevedo C / 2006 / Extraction and analysis of soluble inositol polyphosphates from yeast / Nat Protoc 1:2416~2422
Barker CJ / 2004 / Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle / Biochem J. 380:465~473
Bhandari R / 2008 / Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis / Proc Natl Acad Sci USA 105:2349~2353
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Socio-economic disparity in food consumption among young children in eight South Asian and Southeast Asian countries
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중국 PE 및 PP 시장동향
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PP 투명화기술과 용기포장에 대한 전개
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Mammalian Cell Culture Process Optimization Using Design of Experiment
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Antibacterial Activity of the PP7 Lysis Protein against Pseudomonas aeruginosa Strains
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Unraveling the Signaling Networks of a PP2A-like Phosphatase Sit4 Required for Brain Infection of Cryptococcus neoformans
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Ice-Binding Protein Derived from Glaciozyma Can Improve the Viability of Cryopreserved Mammalian Cells
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Microbial Metabolite in Metabolic Diseases and Drug Responses
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Microbial Metabolites as Inter-Kingdom Signaling Messengers
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Metabolome-Wide Reprogramming Modulated by Wnt/β-Catenin Signaling Pathway
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2016 .01
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Corrigendum to ``Insertion-of-Factors-Property with factors maximal ideals" [J. Korean Math. Soc. 52 (2015), No. 3, pp. 649--661]
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