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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 187 - 194 (8page)
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Inositol phosphates are water-soluble intracellular signaling molecules found in eukaryotes from yeasts to mammals, which are synthesized by a complex network of enzymes including inositol phosphate kinases. Among these, inositol polyphosphate multikinase (IPMK) is a promiscuous enzyme with broad substrate specificity, which phosphorylates multiple inositol phosphates, as well as phosphatidylinositol 4,5-bisphosphate. In addition to its catalytic actions, IPMK is known to non-catalytically control major signaling events via direct protein-protein interactions. In this review, we describe the general characteristics of IPMK, highlight its pleiotropic roles in various physiological and pathological conditions, and discuss future challenges in the field of IPMK signaling pathways.
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참고문헌 (52)
참고문헌 신청
Ahmed, I. / 2015 / Huntington's disease:neural dysfunction linked to inositol polyphosphate multikinase / Proc. Natl. Acad. Sci. U. S. A 112:9751~9756
Bang, S. / 2012 / AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase / Proc. Natl. Acad. Sci. U. S. A 109:616~620
Bechet, J. / 1970 / Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae / Eur. J. Biochem 12:31~39
Berridge, M. J. / 2000 / The versatility and universality of calcium signalling / Nat. Rev. Mol. Cell Biol 1:11~21
Blind, R. D. / 2012 / Direct modification and regulation of a nuclear receptor-PIP2 complex by the inositol lipid kinase IPMK / Sci. Signal 5:ra44
Bang, S. / 2012 / AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase / Proc. Natl. Acad. Sci. U. S. A 109:616~620
Bechet, J. / 1970 / Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae / Eur. J. Biochem 12:31~39
Berridge, M. J. / 2000 / The versatility and universality of calcium signalling / Nat. Rev. Mol. Cell Biol 1:11~21
Blind, R. D. / 2012 / Direct modification and regulation of a nuclear receptor-PIP2 complex by the inositol lipid kinase IPMK / Sci. Signal 5:ra44
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