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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 145 - 153 (9page)
- DOI
- 10.17945/kjbt.2022.33.3.145
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초록· 키워드
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Background: Measurement of ABO isoagglutinin titers is important for patients who have received an ABO-incompatible organ transplant. Specifically, IgG isoagglutinin is essential for predicting graft outcomes in kidney transplantation, but many laboratories measure only the total isoagglutinin taking into consideration time and labor efficiency. In this study, we propose a useful method for predicting IgG isoagglutinin by analyzing the mathematical relationship between total and IgG isoagglutinin titers. Furthermore, the effects of patients’ characteristics of isoagglutinin were also analyzed.
Methods: From January 2017 to April 2022, the results of 3,676 total/IgG isoagglutinin titers of 65 patients who underwent liver and kidney transplantation were analyzed. Isoagglutinin titration was performed using the column agglutination technique with serially diluted serum samples and dithiothreitol was added for measuring IgG isoagglutinin. A generalized estimation equation (GEE) and the Deming regression were used to analyze the relationship and agreement of total/IgG isoagglutinin titers.
Results: In A, B, and O types, total isoagglutinin titers were 1.6 (2^67.1×10–2), 1.9 (2^95.1×10–2), and 2.0 (2^98.5×10–2) times higher than IgG isoagglutinin, respectively, and the agreement between the two tests was high in all blood types. The blood types affected total/IgG isoagglutinin titers (P＜0.05, GEE), but age, sex, and the type of transplanted organs did not have a statistically significant effect.
Conclusion: We concluded that if measuring IgG isoagglutinin titers in ABO-incompatible organ transplant patients is not feasible, the relationship between total and IgG isoagglutinin, viz. total isoagglutinin titers=1.6, 1.9 or 2.0×IgG isoagglutinin for the A, B, and O type blood groups respectively can be used as an auxiliary means of prediction.
(Korean J Blood Transfus 2022;33:145-153)
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