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논문 기본 정보

자료유형
학술저널
저자정보
이영호 (고려대학교) 송관규 (고려대학교)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제23권 제5호
발행연도
2016.1
수록면
304 - 310 (7page)

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Objective. The aim of this study was to analyze published data for an association between consumption of sugar sweetened beverages (SSBs) and the development of gout. Methods. We performed a meta-analysis to examine the highest and lowest categories of SSB consumption in relation to risk of gout. Results. Three studies including 2,606 gout patients among 134,008 participants were included. Meta-analysis revealed a significant association between SSB consumption and gout risk (relative risk [RR]=1.986, 95% confidence interval [CI]=1.447∼2.725, p=2.2×10−5). Stratification by ethnicity showed a significant association between SSB consumption and gout risk in ethnic Europeans, but not in Polynesians (RR=2.110, 95% CI=1.470∼ 2.725, p=5.1×10−5; RR=1.624, 95% CI=0.842∼3.135, p=0.148, respectively). SSB consumption and gout risk were associated in original data and imputed data, for both men and women, regardless of data type and sex. The association between the highest SSB consumption group and gout was stronger than the association between the middle group and gout, indicating a dose-response gradient (RR=1.986, 95% CI=1.447∼2.725, p<2.2×10−5 vs. RR=1.260, 95% CI=1.043∼1.522, p<0.016). Conclusion. This meta-analysis of 134,008 participants demonstrates that SSB consumption is associated with an elevated risk of gout development, particularly in the ethnic European population. Available evidence indicates a dose-response gradient of the relationship between SSB consumption and gout risk. (J Rheum Dis 2016;23:304-310)

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