지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 567 - 573 (7page)
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초록· 키워드
오류제보하기
Purpose Local excision may be an another option for selected patients with markedly down-staged rectal cancer after preoperative chemoradiation therapy (CRT), and proper evaluation of post-CRT tumor stage (ypT) is essential prior to local excision of these tumors. This study was designed to determine the correlations between endoscopic findings and ypT of rectal cancer.
Materials and Methods In this study, 481 patients with locally advanced rectal cancer who underwent preoperative CRT followed by surgical resection between 2004 and 2013 at a single institution were evaluated retrospectively. Pathological good response (p-GR) was defined as ypT ! 1, and pathological minimal or no response (p-MR) as ypT " 2. The patients were randomly classified according to two groups, a testing (n=193) and a validation (n=288) group. Endoscopic criteria were determined from endoscopic findings and ypT in the testing group and used in classifying patients in the validation group as achieving or not achieving p-GR.
Results Based on findings in the testing group, the endoscopic criteria for p-GR included scarring, telangiectasia, and erythema, whereas criteria for p-MR included nodules, ulcers, strictures, and remnant tumors. In the validation group, the kappa statistic was 0.965 (p < 0.001), and the sensitivity, specificity, positive predictive value, and negative predictive value were 0.362, 0.963, 0.654, and 0.885, respectively.
Conclusion The endoscopic criteria presented are easily applicable for evaluation of ypT after preoperative CRT for rectal cancer. These criteria may be used for selection of patients for local excision of down-staged rectal tumors, because patients with p-MR could be easily ruled out.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Sauer R / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351:1731~1740
Sanghera P / 2008 / Chemoradiotherapy for rectal cancer : an updated analysis of factors affecting pathological response / Clin Oncol(R Coll Radiol) 20:176~183
Ikematsu H / 2013 / Long-term outcomes after resection for submucosal invasive colorectal cancers / Gastroenterology 144:551~559
Suh JH / 2012 / Predictors for lymph node metastasis in T1 colorectal cancer / Endoscopy 44:590~595
Lezoche E / 2005 / Long-term results in patients with T2-3 N0 dis-tal rectal cancer undergoing radiotherapy before transanal endoscopic microsurgery / Br J Surg 92:1546~1552
Sanghera P / 2008 / Chemoradiotherapy for rectal cancer : an updated analysis of factors affecting pathological response / Clin Oncol(R Coll Radiol) 20:176~183
Ikematsu H / 2013 / Long-term outcomes after resection for submucosal invasive colorectal cancers / Gastroenterology 144:551~559
Suh JH / 2012 / Predictors for lymph node metastasis in T1 colorectal cancer / Endoscopy 44:590~595
Lezoche E / 2005 / Long-term results in patients with T2-3 N0 dis-tal rectal cancer undergoing radiotherapy before transanal endoscopic microsurgery / Br J Surg 92:1546~1552
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