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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.11
- 수록면
- 697 - 704 (8page)
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Background and Objectives 18F-fluorodeoxyglucose PET/CT scans can be a useful methodto detect recurrence. However, its role in locally advanced head and neck squamous cell carcinomas(HNSCCs) patients after definitive chemoradiotherapy (CRT) has not yet been determined.
The current study was performed to identify the role of therapeutic response evaluation usingPET/CT after definitive CRT.
Subjects and Method We conducted a retrospective review of patients with locally advancedHNSCCs, and who have undergone definitive CRT from 2009 to 2017 at a single institution.
The patients were divided into two groups according to their responses to the treatment(metabolic complete remission [mCR] group or non-mCR group), assessed by PET/CT scansafter definitive CRT.
Results Twenty-eight patients were consecutively enrolled. The most common primary siteof cancer was the oropharynx, followed by the oral cavity, hypopharynx, and nasal cavity.
The therapeutic response assessed by PET/CT scans was mCR in 14 patients. The median progression-free survival (PFS) was not reached in the mCR group but was 13.3 months for thenon-mCR group (p=0.001). The median overall survival was significantly longer for the mCRgroup (52.5 months) than for the non-mCR group (15.2 months, p=0.002). A multivariate analysisshowed PET/CT response and high-sensitivity C-reactive protein (hsCRP) as independentprognostic factors for PFS (mCR: p=0.027; hsCRP: p=0.042) and for the overall survival(mCR: p=0.006; hsCRP: p=0.020).
Conclusion PET/CT scans after definitive CRT predicted the prognosis in patients with locallyadvanced HNSCCs. CRP was a prognostic factor affecting the outcomes of treatments.
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