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학술저널
저자정보
이주영 (충북대학교) 윤순만 (충북대학교) 김정태 (충북대학교) 김기배 (충북대학교) 김미진 (층븍대학교) 박재근 (충북대학교) 이택구 (충북대학교) 이상전 (충북대학교) 궁성수 (충북대학교) 한종호 (충북대학교) 채희복 (충북대학교) 박선미 (충북대학교) 윤세진 (충북대학교)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.15 No.2
발행연도
2017.1
수록면
208 - 214 (7page)

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Background/Aims: 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has beenused for preoperative staging of colorectal cancer (CRC). However, the diagnostic accuracy of FDG-PET/CT for detection oflymph node or distant metastasis and its prognostic role have not been well established. We therefore evaluated the diagnosticand prognostic value of FDG-PET/CT in comparison with conventional CT for CRC. Methods: We investigated 220 patientswho underwent preoperative FDG-PET/CT and CT, followed by curative surgery for CRC. The sensitivity, specificity, accuracy,positive predictive value, and negative predictive value of FDG-PET/CT and CT for detection of lymph node metastasis anddistant metastasis were evaluated. In addition, we assessed the findings of FDG-PET/CT and CT according to outcomes, includingcancer recurrence and cancer-related death, for evaluation of prognostic value. Results: For detection of lymph nodemetastasis, FDG-PET/CT had a sensitivity of 44%, a specificity of 84%, and an accuracy of 67%, compared with 59%, 65%, and62%, respectively, for CT (P =0.029, P =0.000, and P =0.022). For distant metastasis, FDG-PET/CT had a sensitivity of 79%, a specificityof 94%, and an accuracy of 93%, compared with 79%, 87%, and 86%, respectively, for CT (P =1.000, P =0.004, and P =0.037). In addition, positive findings of lymph node metastasis and distant metastasis on FDG-PET/CT were associated significantlywith cancer recurrence or cancer-related death (P =0.009, P =0.001, respectively). Conclusions: Preoperative FDG-PET/CT hada higher specificity and accuracy compared to CT for detection of lymph node metastasis and distant metastasis of CRC. In addition,FDG-PET/CT could be a valuable prognostic tool for CRC.

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