지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 12 (12page)
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Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and venous thrombosis or pregnancy morbidity in patients with persistent antiphospholipid antibodies. However, nationwide population-based epidemiology studies regarding APS are still unavailable. Methods: We analyzed claims data extracted from the Korean Health Insurance and Review Agency (HIRA) covering more than 52 million Koreans, between January 1, 2008, and December 31, 2017. Patients diagnosed with APS, as determined by the Korean Classification of Disease, 7th edition (D68.6), and a rare intractable disease program (V253), were identified in HIRA. Results: A total of 3,088 newly diagnosed incident cases of 1,215 men and 1,873 women were identified during 2009–2016. The mean age was 44.6 ± 16.6 (men, 47.4 ± 16.3; women, 42.8 ± 16.6) years. The incidence was 0.75 per 105 person-year (95% confidence interval, 0.73–0.78). The prevalence in 2016 was 6.19 per 105 people. For incident cases, women showed incidence peak at ages of 30–39 years and 70–79 years, whereas for men, it was highest at ages of 70–79 years only. Of all patients, 1,766 (57%, 810 men and 956 women) had primary APS, 1,322 (43%, 405 men and 917 women) had secondary APS, and 845 (27%, 216 men and 629 women) were associated with systemic lupus erythematosus (SLE). Conclusion: The incidence of APS differs according to age groups and gender. The incidence of primary APS was higher than that of secondary APS in both gender. Furthermore, as already reported, secondary APS is highly associated with SLE; however, we observed that rheumatoid arthritis is also highly related.
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참고문헌 (27)
참고문헌 신청
Miyakis S / 2006 / International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome(APS) / J Thromb Haemost 4(2):295~306
de Jesus GR / 2014 / 14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome / Autoimmun Rev 13(8):795~813
Garcia D / 2018 / Diagnosis and management of the antiphospholipid syndrome / N Engl J Med 378(21):2010~2021
Cervera R / 2015 / Morbidity and mortality in the antiphospholipid syndrome during a 10-year period : a multicentre prospective study of 1000 patients / Ann Rheum Dis 74(6):1011~1018
Uthman I / 2019 / Management of antiphospholipid syndrome / Ann Rheum Dis 78(2):155~161
de Jesus GR / 2014 / 14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome / Autoimmun Rev 13(8):795~813
Garcia D / 2018 / Diagnosis and management of the antiphospholipid syndrome / N Engl J Med 378(21):2010~2021
Cervera R / 2015 / Morbidity and mortality in the antiphospholipid syndrome during a 10-year period : a multicentre prospective study of 1000 patients / Ann Rheum Dis 74(6):1011~1018
Uthman I / 2019 / Management of antiphospholipid syndrome / Ann Rheum Dis 78(2):155~161
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