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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 155 - 161 (7page)
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이 논문의 연구 히스토리 (2)
2015
Anti-inflammatory Efficacy of AP-SF, a Ginsenoside-enriched Fraction, from Korean Ginseng
Kwang-Soo Baek
,
Nak Yoon Sung
,
A
외 3명
한국식품영양과학회 학술대회발표집
2015.08
학술대회자료
Anti-inflammatory activity of AP-SF, a ginsenoside-enriched fraction, from Korean ginseng
Kwang-Soo Baek
,
Yong Deog Hong
,
Yong Kim
외 10명
Journal of Ginseng Research
2015.04
학술저널
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초록· 키워드
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Background: Korean ginseng is an ethnopharmacologically valuable herbal plant with various biological properties including anticancer, antiatherosclerosis, antidiabetic, and anti-inflammatory activities. Since there is currently no drug or therapeutic remedy derived from Korean ginseng, we developed a ginsenoside-enriched fraction (AP-SF) for prevention of various inflammatory symptoms.
Methods: The anti-inflammatory efficacy of AP-SF was tested under in vitro inflammatory conditions including nitric oxide (NO) production and inflammatory gene expression. The molecular events of inflammatory responses were explored by immunoblot analysis.
Results: AP-SF led to a significant suppression of NO production compared with a conventional Korean ginseng saponin fraction, induced by both lipopolysaccharide and zymosan A. Interestingly, AP-SF strongly downregulated the mRNA levels of genes for inducible NO synthase, tumor necrosis factor-a, and cyclooxygenase) without affecting cell viability. In agreement with these observations, AP-SF blocked the nuclear translocation of c-Jun at 2 h and also reduced phosphorylation of p38, c-Jun N-terminal kinase, and TAK-1, all of which are important for c-Jun translocation.
Conclusion: Our results suggest that AP-SF inhibits activation of c-Jun-dependent inflammatory events. Thus, AP-SF may be useful as a novel anti-inflammatory remedy.
Methods: The anti-inflammatory efficacy of AP-SF was tested under in vitro inflammatory conditions including nitric oxide (NO) production and inflammatory gene expression. The molecular events of inflammatory responses were explored by immunoblot analysis.
Results: AP-SF led to a significant suppression of NO production compared with a conventional Korean ginseng saponin fraction, induced by both lipopolysaccharide and zymosan A. Interestingly, AP-SF strongly downregulated the mRNA levels of genes for inducible NO synthase, tumor necrosis factor-a, and cyclooxygenase) without affecting cell viability. In agreement with these observations, AP-SF blocked the nuclear translocation of c-Jun at 2 h and also reduced phosphorylation of p38, c-Jun N-terminal kinase, and TAK-1, all of which are important for c-Jun translocation.
Conclusion: Our results suggest that AP-SF inhibits activation of c-Jun-dependent inflammatory events. Thus, AP-SF may be useful as a novel anti-inflammatory remedy.
목차
abstract
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (46)
참고문헌 신청
1. [학술지(정기간행물)] - Chiurchiù V / 2011 / Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities / Antioxid Redox Signal 15 : 2605 ~ 2641
2. [학술지(정기간행물)] - Leszczynski Przemyslaw / 2013 / ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis / BMB Reports 46 (3) : 139 ~ 150
3. [학술지(정기간행물)] - 강동훈 / 2013 / Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease / Biomolecules & Therapeutics 21 (2) : 89 ~ 96
4. [학술지(정기간행물)] - 박경호 / 2013 / Sphingolipids and Antimicrobial Peptides: Function and Roles in Atopic Dermatitis / Biomolecules & Therapeutics 21 (4) : 251 ~ 257
5. [학술지(정기간행물)] - 이재원 / 2013 / Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-κB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells / Biomolecules & Therapeutics 21 (3) : 216 ~ 221
2. [학술지(정기간행물)] - Leszczynski Przemyslaw / 2013 / ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis / BMB Reports 46 (3) : 139 ~ 150
3. [학술지(정기간행물)] - 강동훈 / 2013 / Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease / Biomolecules & Therapeutics 21 (2) : 89 ~ 96
4. [학술지(정기간행물)] - 박경호 / 2013 / Sphingolipids and Antimicrobial Peptides: Function and Roles in Atopic Dermatitis / Biomolecules & Therapeutics 21 (4) : 251 ~ 257
5. [학술지(정기간행물)] - 이재원 / 2013 / Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-κB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells / Biomolecules & Therapeutics 21 (3) : 216 ~ 221
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UCI(KEPA) : I410-ECN-0101-2018-524-001597691