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Crocin Improves Oxidative Stress by Potentiating Intrinsic Anti-Oxidant Defense Systems in Pancreatic Cells During Uncontrolled Hyperglycemia
Crocin Improves Oxidative Stress by Potentiating Intrinsic Anti-Oxidant Defense Systems in Pancreatic Cells During Uncontrolled Hyperglycemia
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 83 - 89 (7page)
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Crocin Improves Oxidative Stress by Potentiating Intrinsic Anti-Oxidant Defense Systems in Pancreatic Cells During Uncontrolled Hyperglycemia
초록· 키워드
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Introduction: Oxidative stress (OS) during uncontrolled hyperglycemia has a pivotal role in pancreatic dysfunction. Our study aimed to demonstrate that crocin can potentiate anti-oxidant defense systems of pancreatic cells to improve oxidative stress. Methods: Male Wistar rats were divided randomly into four groups: a normal group, a normal-treated group, a diabetic group and a diabetic-treated group (n = 6 rats per group). Diabetes was induced by a single dose of streptozotocin (45 mg/kg/IV). The treated groups received crocin daily for 8 weeks (40 mg/kg/IP). At the end of the experiment, rats were sacrificed and pancreas tissue was obtained. Subsequently, the concentrations of malondialdehyde (MDA), nitrate and glutathione as well as the enzymatic activities of catalase and superoxide dismutase (SOD) were determined in all animals. Data were analyzed by two-way ANOVA with appropriate post hoc testing and a probability value of P < 0.05was considered to represent a statistically significant difference in mean values. Results: Uncontrolled hyperglycemia weakened the anti-oxidant system by decreasing SOD and catalase enzyme activity in pancreatic tissues and induced OS by increasing the MDA content in diabetic non-treated animals. Crocin potentiated the anti-oxidant defense system by increasing the activity of both SOD and catalase, and improved OS by diminishing MDA production in pancreatic cells of rats contained in the diabetic-treated group. Conclusion: Based on our results, it is concluded that uncontrolled hyperglycemia can weaken the anti-oxidant defense system and cause the development of OS. Also, crocin can improve OS in pancreatic cells by potentiating the anti-oxidant defense system.
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참고문헌 (40)
참고문헌 신청
Rains JL / 2011 / Oxidative stress, insulin signaling, and diabetes / Free Radical Biology and Medicine 50(5):567~575
Kashihara N / 2010 / Oxidative stress in diabetic nephropathy / Current medicinal chemistry 17(34):4256
Robertson RP / 2004 / Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes / Journal of Biological Chemistry 279(41):42351~42354
Baynes JW / 1999 / Role of oxidative stress in diabetic complications : a new perspective on an old paradigm / Diabetes 48(1):1~9
Maritim A / 2003 / Diabetes, oxidative stress, and antioxidants: a review / J Biochem Mol Toxicol 17
Kashihara N / 2010 / Oxidative stress in diabetic nephropathy / Current medicinal chemistry 17(34):4256
Robertson RP / 2004 / Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes / Journal of Biological Chemistry 279(41):42351~42354
Baynes JW / 1999 / Role of oxidative stress in diabetic complications : a new perspective on an old paradigm / Diabetes 48(1):1~9
Maritim A / 2003 / Diabetes, oxidative stress, and antioxidants: a review / J Biochem Mol Toxicol 17
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