지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.3
- 수록면
- 49 - 53 (5page)
- DOI
- 10.20307/nps.2021.27.1.49
이용수
초록· 키워드
오류제보하기
Balanophora laxiflora Hemsl. (Balanophoraceae) is a traditional medicinal plant with a diverse array of biological activities. In our exploration of new bioactive constituents from B. laxiflora, we isolated five compounds, including a new lignan, balanophorone (5), and four known phenolic compounds (1–4). The chemical structures of these compounds were determined by extensive spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS, and CD. In addition, we evaluated the effects of each of the isolates (1–5) on the messenger RNA expression levels of tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells. Compound 2 showed significant inhibition of LPS-induced COX-2 and TNF-α expression in RAW 264.7 macrophages, while compound 4 showed moderate cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells, with IC50 values of 18.3 and 30.7 μM, respectively. No significant effects on the viability of normal mammary epithelial cells were observed.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (16)
참고문헌 신청
Nguyen, M. K. / 2016 / List of medicinal plants in Vietnam / Science and Technics Publishing House :628
Do, T. L. / 2014 / Vietnamese medicinal plants and herbs / Medical publisher :114
Wang, X. / 2012 / Chem. Cent. J. 6:79
Ho, S. T. / 2010 / Food Chem 122:584~588
Ho, S. T. / 2012 / Evid. Based Complement. Alternat. Med 2012:1~7
Do, T. L. / 2014 / Vietnamese medicinal plants and herbs / Medical publisher :114
Wang, X. / 2012 / Chem. Cent. J. 6:79
Ho, S. T. / 2010 / Food Chem 122:584~588
Ho, S. T. / 2012 / Evid. Based Complement. Alternat. Med 2012:1~7
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