지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.3
- 수록면
- 32 - 42 (11page)
- DOI
- 10.20307/nps.2025.31.1.32
이용수
초록· 키워드
오류제보하기
Soil microorganisms have been reported to interact with plants, playing key roles such as providing nutrients essential for plant growth and protecting them from plant pathogens. Additionally, various bioactive molecules from soil significantly contribute to controlling diseases threatening human such as cancer and infectious diseases. Considering the crucial roles and potential of these soil microorganisms, the Natural Products Drug Discovery research group (NPDD) at Duksung Women’s University collected soil samples from various environments, isolated fungi from the soil, and aimed to discover bioactive compounds. In this process, 96 fungal strains were cultured on small scale to generate their ethyl acetate extracts, which were subsequently screened for cell viability using MDA-MB-231 triple-negative breast cancer cells. Among them, a subset of 17 with over 60% inhibitory activity were selected as top-performing strains, and other 13 strains with below 60% were chosen for large-scale fermentation candidates by HR-ESI-MS dereplication process to discover new bioactive molecules. Chemical investigation of a part of these large-scale fermentation candidates led to the isolation of 13 major metabolites (1–13), and all isolates were evaluated for their cytotoxicity against MDA-MB-231 cells. As a result, strigaibol C (1), trichoguizaibol J (2), beauvericin (3), and sclerotioramine (13) showed strong inhibitory activities with IC<sub>50</sub> values of 0.99, 0.68, 4.25, and 21.8 μM, respectively.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cytotoxicity against MDA-MB-231 Breast Cancer Cells of Fungal Metabolites of Trichoderma sp. Collected from Medicinal Herbal Garden
Natural Product Sciences
2025 .03
-
Cytotoxic Neoflavonoids and Chalcones from the Heartwood of Dalbergia melanoxylon
Natural Product Sciences
2022 .09
-
Comparison of toxicity of contaminated soil and its soil-extract using soil nematode
환경독성보건학회 심포지엄 및 학술대회
2023 .11
-
Lipid Raft Integrity Is Required for Survival of Triple Negative Breast Cancer Cells
Journal of Breast Cancer
2016 .01
-
Cell viability analysis
대한견주관절의학회 학술대회논문집
2015 .04
-
G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Protein Profiles Associated with Anoikis Resistance of Metastatic MDA-MB-231 Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
New Meroterpenoids from a Penicillium sp. Fungus
Natural Product Sciences
2018 .12
-
Phenolic Constituents from Balanophora laxiflora with their Anti-inflammatory and Cytotoxic Effects
Natural Product Sciences
2021 .03
-
Evaluation of toxicity test conditions for optimal culture of soil algae
환경독성보건학회 심포지엄 및 학술대회
2021 .05
-
Does Spore Count Matter in Fungal Allergy?: The Role of Allergenic Fungal Species
Allergy, Asthma & Immunology Research
2016 .01
-
국내 실외공기의 곰팡이 분포 및 노출에 따른 염증영향평가
한국환경보건학회지
2019 .01
-
Development of a cell-based model to screen the potential toxicity of chemical compounds
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Rhizospheric fungi of Panax notoginseng: diversity and antagonism to host phytopathogens
Journal of Ginseng Research
2016 .04
-
Korean Red Ginseng modulates immune function by upregulating CD4+CD8+ T cells and NK cell activities on porcine
Journal of Ginseng Research
2023 .01
-
Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078
Natural Product Sciences
2015 .12
-
중금속 오염토양 정화 전·후 토양건강성 평가 : 농작물을 대상으로
환경독성보건학회 심포지엄 및 학술대회
2015 .10
-
Toxicity assessment of contaminated soil water using soil algae
환경독성보건학회 심포지엄 및 학술대회
2021 .10
-
EGCG Inhibits Growth of MDA-MB-231 Breast Cancer Cell through the Inactivation of B Catenin Signaling Pathway
대한임상종양학회 학술대회지
2016 .02
-
QGIS를 이용한 토양오염지도 작성
한국환경보건학회지
2019 .01
최근 본 자료
댓글(0)
0