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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 79 - 86 (8page)
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초록· 키워드
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Excessive glutamate causes oxidative stress in neuronal cells, which can cause degenerative neurological disorders. We tried to find medicinal plant showed neuroprotective activity by using glutamate-injured HT22 cell as a model system. In this study, we found that Boesenbergia rotunda methanol extract showed neuroprotective activity against glutamate induced neurotoxicity in mouse hippocampal HT22 cells. B. rotunda methanol extract suppressed the formation of reactive oxygen species and decreased intracellular Ca<SUP>2+</SUP> concentration. Also, B. rotunda made mitochondrial membrane potential maintain to normal levels. In addition, B. rotunda increased total glutathione amount and activated antioxidative enzyme such as glutathione reductase and glutathione peroxidase compared to glutamate-treated groups. These results suggested that B. rotunda decreased neuronal cell death damaged by high concentrations of glutamate treatment, via antioxidative mechanism and might be one of candidate of development of new drug to treat neurodegenerative disease such as Alzheimer’s disease.
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Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (22)
참고문헌 신청
Briggs, R., Kennelly, S. P. and O'Neill, D. (2016) Drug treatments in Alzheimer's disease. Clin. Med. 3: 247-253.
Jeong, G. S., Byun, E., Li, B., Lee, D. S., An, R. B. and Kim, Y. C. (2010) Neuroprotective effects of constituents of the root bark of Dictamnus dasycarpus in mouse hippocampal cells. Arch. Pharm. Res. 33: 1269-1275.
Ha, J. S. and Park, S. S. (2006) Glutamate-induced oxidative stress but not cell death, is largely dependent upon extracellular calcium in mouse neuronal HT22 cells. Neurosci. Lett. 393: 165-169.
Kumar, S., Kain, V. and Sitasawad, S. L. (2012) High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways. Biochim. Biophys. Acta 1820: 907-920.
Tobaben, S., Grohm, J., Seiler, A., Conrad, M., Plesnia, N. and Culmsee, C. (2011) Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Diff. 18: 282-292.
Jeong, G. S., Byun, E., Li, B., Lee, D. S., An, R. B. and Kim, Y. C. (2010) Neuroprotective effects of constituents of the root bark of Dictamnus dasycarpus in mouse hippocampal cells. Arch. Pharm. Res. 33: 1269-1275.
Ha, J. S. and Park, S. S. (2006) Glutamate-induced oxidative stress but not cell death, is largely dependent upon extracellular calcium in mouse neuronal HT22 cells. Neurosci. Lett. 393: 165-169.
Kumar, S., Kain, V. and Sitasawad, S. L. (2012) High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways. Biochim. Biophys. Acta 1820: 907-920.
Tobaben, S., Grohm, J., Seiler, A., Conrad, M., Plesnia, N. and Culmsee, C. (2011) Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Diff. 18: 282-292.
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