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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 27 - 33 (7page)
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초록· 키워드
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Purpose: Stress is associated with depression, which induces many psychiatric disorders. Serotonin, also known as 5-hydroxytryptamine(5-HT), acts as a biochemical messenger and regulator in the brain. It also mediates several important physiologicalfunctions. Depression is closely associated with an overactive bladder. In the present study, we investigated the effect oftreadmill exercise on stress-induced depression while focusing on the expression of 5-HT 1A (5-HT1A) receptors in the dorsalraphe.
Methods: Stress was induced by applying a 0.2-mA electric foot shock to rats. Each set of electric foot shocks comprised a6-second shock duration that was repeated 10 times with a 30-second interval. Three sets of electric foot shocks were appliedeach day for 7 days. For the confirmation of depressive state, a forced swimming test was performed. To visualize the expressionof 5-HT and tryptophan hydroxylase (TPH), immunohistochemistry for 5-HT and TPH in the dorsal raphe was performed.
Expression of 5-HT1A receptors was determined by western blot analysis.
Results: A depressive state was induced by stress, and treadmill exercise alleviated the depression symptoms in the stress-inducedrats. Expressions of 5-HT, TPH, and HT 1A in the dorsal raphe were reduced by the induction of stress. Treadmill exerciseincreased 5-HT, TPH, and HT 1A expressions in the stress-induced rats.
Conclusions: Treadmill exercise enhanced 5-HT synthesis through the up-regulation of 5-HT1A receptors, and improved thestress-induced depression. In the present study, treadmill exercise improved depression symptoms by enhancing 5-HT1A receptorexpression. The present results suggest that treadmill exercise might be helpful for the alleviation of overactive bladderand improve sexual function.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Boldrini M / 2005 / More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides / Brain Res 1041:19~28
Melancon MO / 2012 / Exercise increases tryptophan availability to the brain in older men age 57-70 years / Med Sci Sports Exerc 44:881~887
Greenwood BN / 2005 / Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei / Biol Psychiatry 57:559~568
Milsom I / 2012 / Effect of bothersome overactive bladder symptoms on health-related quality of life, anxiety, depression, and treatment seeking in the United States: results from EpiLUTS / Urology 80:90~96
고일규 / 2013 / Effect of Long-term Exercise on Voiding Functions in Obese Elderly Women / International Neurourology Journal 17(3):130~138
Melancon MO / 2012 / Exercise increases tryptophan availability to the brain in older men age 57-70 years / Med Sci Sports Exerc 44:881~887
Greenwood BN / 2005 / Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei / Biol Psychiatry 57:559~568
Milsom I / 2012 / Effect of bothersome overactive bladder symptoms on health-related quality of life, anxiety, depression, and treatment seeking in the United States: results from EpiLUTS / Urology 80:90~96
고일규 / 2013 / Effect of Long-term Exercise on Voiding Functions in Obese Elderly Women / International Neurourology Journal 17(3):130~138
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