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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 31 - 37 (7page)
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Glutamate-induced oxidative stress results in neuro-degenerative disorders in many central nervous system (CNS) such as Alzheimer`s disease, ischemia, Huntington`s disease, and Parkinson`s disease. Our study was performed to investigate neuroprotective effects of Allium hookeri extracts (leaf, root, and whole) on glutamate-induced HT22 cells. In this study, ethanol extract of A. hookeri showed the outstanding neuroprotective effect in HT22 cells. In addition, we found that ethanol extract of A. hookeri root increased heme oxygenase (HO)-1 in HT22 cells. Moreover, ethanol extract of A. hookeri root also upregulated nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2) in HT22 cells. These results demonstrate that ethanol extract of A. hookeri root contributes neuroprotective effects against glutamate-induced oxidative stress in HT22 cells, via Nrf2- mediated HO-1 expression. Our study suggests that ethanol extract of A. hookeri root could be the potential agent for the treatment of many neuro-degenerative diseases.
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참고문헌 (32)
참고문헌 신청
Jin, D. Q. / 2005 / Anti-oxidant and anti-inflammatory activity of macelignan in murine hippocampal cell line and primary culture of rat microglial cell / Biochem. Biophys. Res. Commun 331:1264~1269
Lim, C. S. / 2006 / Antioxidant and anti-inflammatory activities of the methanolic extract of Neorhodomela aculeate in hippocampal and microglial cells / Biol. Pharm. Bull 29:1212~1216
Satoh, T. / 1999 / Oxygen toxicity induces apoptosis in neuronal cells / Cell Mol. Neurobiol 18:649~666
Coyle, J. T / 1993 / Oxidative stress,glutamate and neurodegenerative disorders / Science. 262:689~695
Frei B. / 1994 / Natural Antioxidants in Human Health and Disease / Academic Press :25~55
Lim, C. S. / 2006 / Antioxidant and anti-inflammatory activities of the methanolic extract of Neorhodomela aculeate in hippocampal and microglial cells / Biol. Pharm. Bull 29:1212~1216
Satoh, T. / 1999 / Oxygen toxicity induces apoptosis in neuronal cells / Cell Mol. Neurobiol 18:649~666
Coyle, J. T / 1993 / Oxidative stress,glutamate and neurodegenerative disorders / Science. 262:689~695
Frei B. / 1994 / Natural Antioxidants in Human Health and Disease / Academic Press :25~55
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