Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)

Csaba Fernye; Zsolt Ancsin; Andrea Bócsai; Krisztián Balogh; Miklós Mézes; Márta Erdélyi

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자료유형: 학술저널

저자정보: Csaba Fernye (Szent István University) Zsolt Ancsin (Szent István University) Andrea Bócsai (Szent István University) Krisztián Balogh (Szent István University) Miklós Mézes (Szent István University) Márta Erdélyi (Szent István University)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.34 No.3

발행연도: 2018.7

수록면: 249 - 257 (9page)

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The purpose of the present study was to evaluate the effects of different dietary concentrations of T-2 toxin on blood plasma protein content, lipid peroxidation and glutathione redox system of pheasant (Phasianus colchicus). A total of 320 one-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with different concentrations of T-2 toxin (control, 4 ㎎/㎏, 8 ㎎/㎏ and 16 ㎎/㎏). Birds were sacrificed at early (12, 24 and 72 hr) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the effect of T-2 toxin on lipid peroxidation and glutathione redox status in different tissues. Feed refusal and impaired growth were observed with dose dependent manner. Lipid-peroxidation was not induced in the liver, while the glutathione redox system was activated partly in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Based on our results, pheasants seem to have higher tolerance to T-2 toxin than other avian species, and glutathione redox system might contribute in some extent to this higher tolerance, in particular against free-radical mediated oxidative damage of tissues, such as liver.

#Lipid peroxidation #Antioxidant defense #Malondialdehyde #Reduced glutathione #Glutathione peroxidase

참고문헌 (53)

참고문헌 신청

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