Evaluation of Phenolic Content Diversity along with Antioxidant/Pro-Oxidant, Glutathione Transferase Inhibition, and Cytotoxic Potential of Selected Commonly Used Plants

Rasha Awni Guneidy; Eman Ragab Zaki; Abdul Aziz Mohamed Gad; Nevein Salah El-Din Saleh; Abeer Shokeer

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저자정보: Rasha Awni Guneidy (National Research Center) Eman Ragab Zaki (National Research Center) Abdul Aziz Mohamed Gad (National Research Center) Nevein Salah El-Din Saleh (National Research Center) Abeer Shokeer (National Research Center)

저널정보: 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.27 No.3

발행연도: 2022.9

수록면: 282 - 298 (17page)

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The function of antioxidant polyphenols has been demonstrated for their ability to protect against a variety of diseases. However, some antioxidants have been shown to be pro-oxidant. Some of the important antioxidant enzymes are glutathione transferases (GST), which are involved in maintaining redox homeostasis. GST class Pi (GSTP1-1) hyper-activation is a feature that is found in cancer. This work aims to demonstrate the relationship between the phytochemicals of 18 plants and their ability to act as antioxidant/pro-oxidant agents, as well as their effects on the activity of GSTP1-1 and their cellular toxicity. Tamarindus indica, Cinnamomum verum, and Alpinia galanga extracts had high phytochemical contents, moderate heavy metal levels, and antioxidant/pro-oxidant activities. Among the main plant components identified using high-performance liquid chromatography, only chlorogenic acid, catechin, and quercetin can function as antioxidants and pro-oxidants. Hibiscus sabdariffa, C. verum, A. galanga, T. indica, Gossypium arboreum, and Punica granatum were among the plant extracts examined that inhibited the activity of the purified recombinant GSTP1-1, with the inhibition constant values ranging from 0.48 to 1.67 mg of gallic acid equivalent/g. The level of cytotoxicity was also studied to determine the effects of these extracts on human Caucasian breast cancer. The findings revealed that plants with high phenol content had an antioxidant/pro-oxidant capacity as well as inhibition of the activity of GST. However, the cytotoxic effect was not associated with all of the extracts, which indicates that polyphenols interact with other components that may influence their observed behavior.

#antioxidant capacity #cytotoxicity #glutathione transferase inhibition #polyphenol compounds #pro-oxidant activity

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