지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 187 - 192 (6page)
이용수
초록· 키워드
오류제보하기
The goal of this study was to determine whether gypenosides (GPS) exert protective effects against dopaminergic neuronal cell death in a 6-hydroxydopamine (OHDA)-lesioned rat model of Parkinson’s disease (PD) with or without long-term 3,4-dihydroxyphenylalanine (L-DOPA) treatment. Rats were injected with 6- OHDA in the substantia nigra to induce PD-like symptoms; 14 days after injection, groups of 6-OHDA-lesioned animals were treated for 21 days with GPS (25 or 50 mg/kg) and/or L-DOPA (20 mg/kg). Dopaminergic neuronal cell death was assessed by counting tyrosine hydroxylase (TH)-immunopositive cells in the substantia nigra and measuring levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in the striatum. Dopaminergic neuronal cell death induced by 6-OHDA lesions was ameliorated by GPS treatment (50 mg/kg). L-DOPA treatment exacerbated 6-OHDA-induced dopaminergic neuronal cell death; however, these effects were partially reversed by GPS treatment (25 and 50 mg/kg). These results suggest that GPS treatment is protective against dopaminergic neuronal cell death in a 6-OHDA-lesioned rat model of PD with long-term L-DOPA treatment. Therefore, GPS may be useful as a phytotherapeutic agent for the treatment of PD.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protective effects of Humulus Japonicus on dopaminergic cell death in Parkinson’s disease
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Changes in the Neuronal Architecture of the Hippocampus in a 6-Hydroxydopamine-Lesioned Rat Model of Parkinson Disease
International Neurourology Journal
2022 .11
-
6-Hydroxydopamine으로 유도된 질소적 세포 사멸에 대한 고려홍삼 추출물의 보호효과
약학회지
2016 .01
-
Impaired Voluntary Wheel Running Behavior in the Unilateral 6-Hydroxydopamine Rat Model of Parkinson's Disease
대한신경외과학회지
2015 .01
-
Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson’s disease mouse model
Journal of Ginseng Research
2015 .04
-
7,8,4'-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Fucoidan attenuates 6-hydroxydopamine-induced neurotoxicity by exerting anti-oxidative and anti-apoptotic actions in SH-SY5Y cells
Korean Journal of Veterinary Research(대한수의학회지)
2017 .04
-
Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine
Journal of Biomedical and Translational Research
2020 .01
-
Dynamic study를 이용한 선조체에서의 <sup>18</sup>F-DOPA의 분포에 대한 평가
핵의학기술
2015 .01
-
Impact of deep brain stimulation on non-motor symptoms in Parkinson’s disease
Journal Of Movement Disorders
2024 .04
-
Dopaminergic neuronal development in the embryonic mesencephalon of Mice
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Dopamine D1-like receptor regulates GAD-67 expression following degeneration of dopaminergic neuron
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Subthalamo-pallidal and pallido-subthalamic connectivity alterations in a 6-OHDA Parkinson's disease mouse model via 9.4T diffusion MRI
한국실험동물학회 학술발표대회 논문집
2025 .02
-
The Evaluation of hES cell-derived Dopaminergic Precursor Cells in MPTP induced Parkinson"s disease model with Common marmoset
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Bone Regeneration Using Block-type Deproteinized Porcine Bone Mineral with Collagen Membrane Using 3,4-Dihydroxyphenylalanine as Bone Adhesive
Journal of Korean Dental Science
2018 .12
-
Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
대한신경외과학회지
2017 .01
-
Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson’s disease mouse model
Journal of Ginseng Research
2018 .10
-
Evaluation method based non-invasive imaging in Parkinson’s disease models
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Glasgow prognostic score and combined positive score for locally advanced rectal cancer
Annals of Surgical Treatment and Research
2022 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-518-000061353