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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제21권 제4호
- 발행연도
- 2020.1
- 수록면
- 165 - 170 (6page)
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Dopamine (DA) receptor (D1 and D2-like receptors) agonists are known to affect expression levels of DA receptors. Rotigotine, a DA D2-like receptor agonist, has been developed for treating Parkinson’s disease (PD). However, its role in PD by acting through DA D2-like receptors has not been fully understood yet. The purpose of this study was to investigate neuroprotective effects of rotigotine through DA D2 and D3 receptors in 6-hydroxydopamine (6-OHDA) induced mouse model of PD. Expression level of tyrosine hydroxylase (TH) was examined using immunohistochemistry and Western blot analysis. Results revealed that unilateral injection of 6-OHDA into the midbrain caused significant loss of TH positive cells in the substantia nigra, whereas rotigotine inhibited such loss of TH cells in 6-OHDA-induced mouse model of PD. In vitro experiments demonstrated that rotigotine increased expression levels of TH against 6-OHDA-induced toxicity. The expression level of TH after treatment with L’741,626, a D2 receptor antagonist was decreased more than that after treatment with GR 103691, a D3 receptor antagonist. These results suggest that rotigotine can protect DA neurons against 6-OHDA induced toxicity and that the protective effect of rotigotine for DAergic neurons through a DA D2 receptor is stronger than that through a DA D3 receptor.
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참고문헌 (25)
참고문헌 신청
Bjӧrklund A / 2007 / Dopamine neuron systems in the brain : an update / Trends Neurosci 30:194~202
Damier P / 1999 / The substantia nigra of the human brain. Ⅱ. patterns of loss of dopaminecontaining neurons in Parkinson’s desease / Brain 122:1437~1448
Schultz W / 2001 / Reward signaling by dopamine neurons / Neuro-scientist 7:293~302
Krabbe S / 2015 / Increased dopa-mine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area / Proc Natl Acad Sci USA 112:E1498~E1506
Beaulieu JM / 2011 / The physiology, signaling, and pharmacology of dopamine receptors / Pharmacol Rev 63:182~217
Damier P / 1999 / The substantia nigra of the human brain. Ⅱ. patterns of loss of dopaminecontaining neurons in Parkinson’s desease / Brain 122:1437~1448
Schultz W / 2001 / Reward signaling by dopamine neurons / Neuro-scientist 7:293~302
Krabbe S / 2015 / Increased dopa-mine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area / Proc Natl Acad Sci USA 112:E1498~E1506
Beaulieu JM / 2011 / The physiology, signaling, and pharmacology of dopamine receptors / Pharmacol Rev 63:182~217
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