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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 148 - 154 (7page)
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초록· 키워드
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Background: Ginseng is known to have antiapoptotic, anti-inflammatory, and antioxidant effects. The present study investigated a possible role of Korean Red Ginseng (KRG) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in the substantia nigra (SN) and striatum (ST) using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease mouse model. Methods: Ten-week-old male C57BL/6 mice were injected intraperitoneally with 30 mg/kg of MPTP at 24-h intervals for 5 d, and then administered KRG (1 mg/kg, 10 mg/kg, or 100 mg/kg) once a day for 12 consecutive days from the first injection. Pole tests were performed to assess the motor function of the mice, dopaminergic neuronal survival in the SN and ST was evaluated using tyrosine hydroxylase-immunohistochemistry, and the expressions of cyclin-dependent kinase 5 (Cdk5), p35, and p25 in the SN and ST were measured using Western blotting.
Results: MPTP administration caused behavioral impairment, dopaminergic neuronal death, increased Cdk5 and p25 expression, and decreased p35 expression in the nigrostriatal system of mice, whereas KRG dose-dependently alleviated these MPTP-induced changes.
Conclusion: These results indicate that KRG can inhibit MPTP-induced dopaminergic neuronal death and suppress the cleavage of p35 to p25 in the SN and the ST, suggesting a possible role for KRG in the treatment of Parkinson’s disease.
Results: MPTP administration caused behavioral impairment, dopaminergic neuronal death, increased Cdk5 and p25 expression, and decreased p35 expression in the nigrostriatal system of mice, whereas KRG dose-dependently alleviated these MPTP-induced changes.
Conclusion: These results indicate that KRG can inhibit MPTP-induced dopaminergic neuronal death and suppress the cleavage of p35 to p25 in the SN and the ST, suggesting a possible role for KRG in the treatment of Parkinson’s disease.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Kurosaki R / 2004 / Biochemical, behavioral, and immunohistochemical alterations in MPTP-treated mouse model of Parkinson’s disease / Pharmacol Biochem Behav 78 : 143 ~ 153
2. [학술지(정기간행물)] - Kanungo J / 2009 / Targeting Cdk5 activity in neuronal degeneration and regeneration / Cell Mol Neurobiol 29 : 1073 ~ 1080
3. [학술지(정기간행물)] - Cruz JC / 2004 / A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease / Curr Opin Neurobiol 14 : 390 ~ 394
4. [학술지(정기간행물)] - Cheung ZH / 2008 / Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2 / J Neurosci 28 : 4872 ~ 4877
5. [학술지(정기간행물)] - Zheng YL / 2007 / Cdk5 modulation of mitogen-activated protein kinase signaling regulates neuronal survival / Mol Biol Cell 18 : 404 ~ 413
2. [학술지(정기간행물)] - Kanungo J / 2009 / Targeting Cdk5 activity in neuronal degeneration and regeneration / Cell Mol Neurobiol 29 : 1073 ~ 1080
3. [학술지(정기간행물)] - Cruz JC / 2004 / A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease / Curr Opin Neurobiol 14 : 390 ~ 394
4. [학술지(정기간행물)] - Cheung ZH / 2008 / Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2 / J Neurosci 28 : 4872 ~ 4877
5. [학술지(정기간행물)] - Zheng YL / 2007 / Cdk5 modulation of mitogen-activated protein kinase signaling regulates neuronal survival / Mol Biol Cell 18 : 404 ~ 413
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UCI(KEPA) : I410-ECN-0101-2018-524-001597686