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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 219 - 219 (1page)
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초록· 키워드
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Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons in the nigrostriatal system. To monitor the PD, PET with [18F]FP-CIT for the dopamine transporter (DAT) has become a widely used tool. For PD study, invaluable tools are neurotoxin-based animal models. To validate the usefulness of these animal models in DAT imaging, we discuss the evaluation of these models. To develop most classical neurotoxin PD animal models, we injected 6-hydroxydopamine (6-OHDA) into the substantia nigra of mouse or treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by oral routes. After that, [18F]FP-CIT PET imaging were acquired. The changes in [18F]FP ... 전체 초록 보기
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