지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 20 - 27 (8page)
이용수
초록· 키워드
오류제보하기
Non-polio enteroviruses (NPEVs) are primary causative agents of aseptic meningitis, encephalitis, hand, foot and mouth disease (HFMD), and myocarditis in infants and children and immunocompromised individuals. However, there are no approved treatments for NPEVs. It has been reported that flavonoids are abundantly found in plants and have antiviral activities. In this study, we explored the antiviral potential of quercetin-3-glucoside (Q3G), a natural flavonoid, against NPEVs such as coxsackievirus A16 and B3 (CVA16 and CVB3), enterovirus 71 (EV71), and human rhinovirus 1B (HRV 1B). Q3G showed potent antiviral activity against CVA16, CVB3, EV71, and HRV1B by suppressing the expression of viral RNA at the early stages of infection. Therefore, Q3G inhibits the early stages of the viral replication cycle and may provide an essential alternative for treating EV71, CVB3, CVA16, and HRV1B.
목차
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Streptomyces Extract Inhibits Enterovirus 71 Replication by Activation of PKB/AKT Signaling
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2017 .09
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UCI(KEPA) : I410-ECN-0101-2022-475-001315052