지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 질병관리본부 Osong Public Health and Research Persptectives Osong Public Health and Research Perspectives 제6권 제1호
- 발행연도
- 2015.2
- 수록면
- 52 - 58 (7page)
이용수
초록· 키워드
오류제보하기
Objectives: Coxsackievirus A group 16 strain (CVA16) is one of the predominant causative agents of hand, foot, and mouth disease (HFMD). Methods: Using a specimen from a male patient with HFMD, we isolated and performed sequencing of the Korean CVA16 strain and compared it with a G10 reference strain. Also, we were investigated the effects of medicinal plant extract on the cytopathic effects (CPE) by CPE reduction assay against Korean CVA16. Results: Phylogenetic analysis showed that the Korean CVA16 isolate belonged to cluster B-1 and was closely related to the strain PM-15765-00 isolated in Malaysia in 2000. The Korean CVA16 isolate showed 73.2% nucleotide identity to the G10 prototype strain and 98.7% nucleotide identity to PM-15765-00. Next, we assessed whether the Korean CVA16 isolate could be used for in vitro screening of antiviral agents to treat HFMD infection. Vero cells infected with the Korean CVA16 isolate showed a cytopathiceffect 2 days after the infection, and the treatment of cells with Cornus officinalis, Acer triflorum, Pulsatilla koreana, and Clematis heracleifolia var. davidiana Hemsl extracts exhibited strong antiviral activity against CVA16. Conclusion: Collectively, our work provides potential candidates for the development of vaccine and novel drugs to treat the CVA16 strain isolated from a Korean patient.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Bendig JW / 1996 / Epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease in England and Wales / Commun Dis Rep CDR Rev 6(6):R81~R86
Chang LY / 1998 / Fulminant neurogenic pulmonary oedema with hand, foot, and mouth disease / Lancet 352(9125):367~368
Iwai M / 2007 / Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007 / Jpn J Infect Dis 62(4):254~259
Rabenau HF / 2010 / Hand, foot and mouth disease:seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany / Med Microbiol Immunol 199(1):45~51
Ang LW / 2009 / Epidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007 / Ann Acad Med Singapore 38(2):106~112
Chang LY / 1998 / Fulminant neurogenic pulmonary oedema with hand, foot, and mouth disease / Lancet 352(9125):367~368
Iwai M / 2007 / Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007 / Jpn J Infect Dis 62(4):254~259
Rabenau HF / 2010 / Hand, foot and mouth disease:seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany / Med Microbiol Immunol 199(1):45~51
Ang LW / 2009 / Epidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007 / Ann Acad Med Singapore 38(2):106~112
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