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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 질병관리본부 Osong Public Health and Research Persptectives Osong Public Health and Research Persptectives Vol.7 No.6
- 발행연도
- 2016.1
- 수록면
- 400 - 403 (4page)
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초록· 키워드
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Human rhinoviruses and enteroviruses (family Picornaviridae) infect millions of people worldwide each year, but little is known about effective therapeutical treatment for the infection caused by these viruses. We sought to determine whether or not Zanthoxylum (Rutaceae) species can exhibit antiviral activity against picornaviruses. The leaf parts of four Zanthoxylum species were extracted with methanol, and the extracts were investigated for their antiviral activity against picornaviruses using cytopathic effects by cytopathic effect reduction. Leaf extracts of Zanthoxylum piperitum among four Zanthoxylum species were found to possess only broad-spectrum antipicornavirus activity against human rhninovirus 2 with a 50% inhibitory concentration (IC50) value of 59.48 ㎍/mL, human rhinovirus 3 with an IC50 value of 39.94 ㎍/mL, coxsackie A16 virus with an IC50 value of 45.80 ㎍/mL, coxsackie B3 virus with an IC50 value of 68.53 ㎍/mL, coxsackie B4 virus with an IC50 value of 93.58 ㎍/mL, and enterovirus 71 virus with an IC50 value of 4.48 ㎍/mL. However, ribavirin did not possess antiviral activity against human rhinovirus 3 and four enteroviruses. Therefore, leaves of Z. piperitum showed broad-spectrum antipicornavirus activity, and may be useful as a candidate for studying picornavirus agents and development of pharmaceuticals.
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참고문헌 (16)
참고문헌 신청
Makela MJ / 1998 / Viruses and bacteria in the etiology of the common cold / J Clin Microbiol 36(2):539~542
Whitton JL / 2005 / Host and virus determinants of picornavirus pathogenesis and tropism / Nat Rev Microbiol 3(10):765~776
Imakita M / 2000 / Pneumonia caused by rhinovirus / Clin Infect Dis 30(3):611~612
Gutman JA / 2007 / Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: a report of two cases / Bone Marrow Transplant 40(8):809~811
Renwick N / 2007 / A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany / J Infect Dis 196(12):1754~1760
Whitton JL / 2005 / Host and virus determinants of picornavirus pathogenesis and tropism / Nat Rev Microbiol 3(10):765~776
Imakita M / 2000 / Pneumonia caused by rhinovirus / Clin Infect Dis 30(3):611~612
Gutman JA / 2007 / Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: a report of two cases / Bone Marrow Transplant 40(8):809~811
Renwick N / 2007 / A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany / J Infect Dis 196(12):1754~1760
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