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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 291 - 297 (7page)
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초록· 키워드
오류제보하기
Coxsackievirus B3 (CVB3) is a very well-known causative agent for viral myocarditis and meningitis in human. However, the effective vaccine and therapeutic drug are not developed yet. CVB3 infection activates host cell AKT signaling. Inhibition of AKT signaling pathway may attenuate CVB3 replication and prevent CVB3-mediate viral myocarditis. In this study, we determined antiviral effect of the selected natural plant extract to develop a therapeutic drug for CVB3 treatment. We screened several chemically extracted natural compounds by using HeLa cell-based cell survival assay. Among them, Linum usitatissimum L. extract was selected for antiviral drug candidate. L. usitatissimum extract significantly decreased CVB3 replication and cell death in CVB3 infected HeLa cells with no cytotoxicity. CVB3 protease 2A induced eIF4G1 cleavage and viral capsid protein VP1 production were dramatically decreased by L. usitatissimum extract treatment. In addition, virus positive and negative strand genome amplification were significantly decreased by 1 mg/ml L. usitatissimum extract treatment. Especially, L. usitatissimum extract was associated with inhibition of AKT signal and maintain mTOR activity. In contrast, Atg12 and LC3 expression were not changed by L. usitatissimum extract treatment. In this study, the potential AKT signal inhibitor, L. usitatissimum extract, was significantly inhibited viral genome replication and protein production by inhibition of AKT signal. These results suggested that L. usitatissimum extract is a novel therapeutic agent for treatment of CVB3-mediated diseases.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Feldman, A. M. / 2000 / Myocarditis / N. Engl. J. Med 343:1388~1398
Lim, B. K. / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest 118:2758~2770
이윤경 / 2016 / Fructus Amomi Cardamomi Extract Inhibits Coxsackievirus-B3 Induced Myocarditis in a Murine Myocarditis Model / Journal of Microbiology and Biotechnology 26(11):2012~2018
Herskowitz, A. / 1985 / Coxsackievirus B3 murine myocarditis: wide pathologic spectrum in genetically defined inbred strains / Hum. Pathol 16:671~673
Baboonian, C. / 1997 / Coxsackie B viruses and human heart disease / Curr. Top. Microbiol. Immunol 223:31~52
Lim, B. K. / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest 118:2758~2770
이윤경 / 2016 / Fructus Amomi Cardamomi Extract Inhibits Coxsackievirus-B3 Induced Myocarditis in a Murine Myocarditis Model / Journal of Microbiology and Biotechnology 26(11):2012~2018
Herskowitz, A. / 1985 / Coxsackievirus B3 murine myocarditis: wide pathologic spectrum in genetically defined inbred strains / Hum. Pathol 16:671~673
Baboonian, C. / 1997 / Coxsackie B viruses and human heart disease / Curr. Top. Microbiol. Immunol 223:31~52
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