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자료유형
학술저널
저자정보
Lee, Dong Seong (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Lee, Young Il (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Ahn, Jeong Bae (Division of Vaccine Research, Center for Infectious Disease, Korea National Institute of Health, Korea Centers for Disease Control and Prevention) Kim, Mi Jin (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Kim, Jae Hyun (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Kim, Nam Hee (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Hwang, Jong Hee (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Kim, Dong Wook (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Lee, Chong Guk (Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine) Song, Tae Won (Department of Pediatrics, Inje University Il)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제58권 제3호
발행연도
2015.1
수록면
112 - 115 (4page)

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Hand, foot, and mouth disease (HFMD) is an acute, mostly self-limiting infection. Patients usually recover without any sequelae. However, a few cases are life threatening, especially those caused by enterovirus 71 (EV71). A 12-month-old boy was admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet. After 3 days, he experienced 3 seizure episodes and was referred to our hospital. On admission, he was conscious and his chest radiograph was normal. However, 6 hours later, he suddenly lost consciousness and had developed a massive pulmonary hemorrhage that continued until his death. He experienced several more intermittent seizures, and diffuse infiltration of both lung fields was observed on chest radiography. Intravenous immunoglobulin, dexamethasone, cefotaxime, leukocyte-depleted red blood cells, fresh frozen plasma, inotropics, vitamin K, and endotracheal epinephrine were administered. The patient died 9 hours after intubation, within 3 days from fever onset. EV71 subgenotype C4a was isolated retrospectively from serum and nasopharyngeal swab by real-time reverse transcription-polymerase chain reaction. Here, we report a fatal case of EV71-associated HFMD with sudden-onset massive pulmonary hemorrhage and suspected encephalitis.

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