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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.68 No.5
- 발행연도
- 2015.1
- 수록면
- 488 - 495 (8page)
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초록· 키워드
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Background: Propofol has been reported to protect vascular endothelial cells against oxidative stress. In this study we investigated its effect on hydrogen peroxide (H2O2)-induced apoptosis of human umbilical vein endothelial cells (HUVECs) and examined the possible signaling pathways. Methods: HUVECs were pretreated with propofol (1, 5, 25, and 50 μM) for 30 min and then co-incubated with 0.4 mM H2O2 for 4 h. Cell viability was assessed using a Cell Counting Kit-8. Cell apoptosis was analyzed using flow cytometry with annexin V/propidium iodide staining, and evaluated by quantifying caspase-3, Bax, and Bcl-2 expression levels. The expression levels of p38 mitogen activated protein kinase (MAPK), phosphorylated (p)-p38 MAPK, cJun-N-terminal kinases (JNK), phosphorylated (p)-JNK, Akt and phosphorylated Akt [(p)-Akt] (Ser473) were measured by western blotting. Results: H2O2 treatment induced the activation of caspase-3, downregulated Bcl-2 expression, and up-regulated Bax expression, all of which were dose-dependently attenuated by propofol pretreatment. Furthermore, propofol significantly ameliorated H2O2-induced phosphorylation of p38 MAPK, JNK, and Akt in HUVECs. Conclusions: Propofol can protect HUVECs against H2O2-induced apoptosis via a mechanism that may involve p38 MAPK, JNK, and Akt signaling pathways.
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참고문헌 (28)
참고문헌 신청
Cai H. / 2005 / Hydrogen peroxide regulation of endothelial function : origins, mechanisms, and consequences / Cardiovasc Res 68:26~36
Chen J / 2010 / Propofol protects against hydrogen peroxide-induced oxidative stress and cell dysfunction in human umbilical vein endothelial cells / Mol Cell Biochem 339:43~54
Wang B / 2007 / Propofol reduces apoptosis and up-regulates endothelial nitric oxide synthase protein expression in hydrogen peroxide-stimulated human umbilical vein endothelial cells / Anesth Analg 105:1027~1033
Ryter SW / 2007 / Mechanisms of cell death in oxidative stress / Antioxid Redox Signal 9:49~89
Murphy PG / 1992 / The antioxidant potential of propofol(2, 6-diisopropylphenol) / Br J Anaesth 68:613~618
Chen J / 2010 / Propofol protects against hydrogen peroxide-induced oxidative stress and cell dysfunction in human umbilical vein endothelial cells / Mol Cell Biochem 339:43~54
Wang B / 2007 / Propofol reduces apoptosis and up-regulates endothelial nitric oxide synthase protein expression in hydrogen peroxide-stimulated human umbilical vein endothelial cells / Anesth Analg 105:1027~1033
Ryter SW / 2007 / Mechanisms of cell death in oxidative stress / Antioxid Redox Signal 9:49~89
Murphy PG / 1992 / The antioxidant potential of propofol(2, 6-diisopropylphenol) / Br J Anaesth 68:613~618
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