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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 169 - 178 (10page)
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L-ascorbic acid (L-AA; vitamin C) induces apoptosis in cancer cells. This study aimed to elucidate the molecular mechanisms of L-AA-induced apoptosis in human laryngeal epidermoid carcinoma Hep-2 cells. L-AA suppressed the viability of Hep-2 cells and induced apoptosis, as shown by the cleavage and condensation of nuclear chromatin and increased number of Annexin V-positive cells. L-AA decreased Bcl-2 protein expression but upregulated Bax protein levels. In addition, cytochrome c release from the mitochondria into the cytosol and activation of caspase-9, -8, and -3 were enhanced by L-AA treatment. Furthermore, apoptosis-inducing factor (AIF) and endonuclease G (EndoG) were translocated into the nucleus during apoptosis of L-AA-treated Hep-2 cells. L-AA effectively inhibited the constitutive nuclear factor-κB (NF-κB) activation and attenuated the nuclear expression of the p65 subunit of NF-κB. Interestingly, L-AA treatment of Hep-2 cells markedly activated Akt and mitogen-activated protein kinase (MAPK; extracellular signal-regulated kinase 1/2, p38, and c-Jun N-terminal kinase [JNK]) and and LY294002 (Akt inhibitor), SB203580 (p38 inhibitor) or SP600125 (a JNK inhibitor) decreased the levels of Annexin V-positive cells. These results suggested that L-AA induces the apoptosis of Hep-2 cells via the nuclear translocation of AIF and EndoG by modulating the Bcl- 2 family and MAPK/Akt signaling pathways.
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참고문헌 (33)
참고문헌 신청
Arlene A. Forastiere / 2003 / Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer / New England Journal of Medicine 349(22):2091~2098
Dechaphunkul T / 2011 / Epidemiology, risk factors, and overall survival rate of laryngeal cancer in Songklanagarind Hospital / J Med Assoc Thai 94:355~360
Mashima T / 1996 / Cancer chemotherapy and apoptosis / Nihon Rinsho 54:1935~1942
Schwartz LH / 1994 / Antioxidant minerals and vitamins. Role in cancer prevention / Presse Med 23:1826~1830
K. Charalabopoulos / 2003 / Inhibition of Benzo(a)pyrene-Induced Carcinogenesis by Vitamin C Alone and by Vitamin C/Vitamin E and Selenium/Glutathione / Biological Trace Element Research 93(1-3):201~212
Dechaphunkul T / 2011 / Epidemiology, risk factors, and overall survival rate of laryngeal cancer in Songklanagarind Hospital / J Med Assoc Thai 94:355~360
Mashima T / 1996 / Cancer chemotherapy and apoptosis / Nihon Rinsho 54:1935~1942
Schwartz LH / 1994 / Antioxidant minerals and vitamins. Role in cancer prevention / Presse Med 23:1826~1830
K. Charalabopoulos / 2003 / Inhibition of Benzo(a)pyrene-Induced Carcinogenesis by Vitamin C Alone and by Vitamin C/Vitamin E and Selenium/Glutathione / Biological Trace Element Research 93(1-3):201~212
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