지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 150 - 156 (7page)
- DOI
- 10.15188/kjopp.2016.06.30.3.150
이용수
이 논문의 연구 히스토리 (3)
2016
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Extract of Broussometia kazinoki Rhizodermatis has been traditionally used for geopoong, diuresis, hwalhyeol. In the present study, the apoptotic effect of methanol extract of Broussometia kazinoki (MBK) were investigated. Cell viability of A549 cells was measured by MTT assay. Apoptosis-related protein and MAPK protein levels were measured by Western blot. Chromatin condensation of A549 cells was stained with DAPI. MBK inhibited cell proliferation of A549 cell. Based on DAPI staining, MBK-treated cells manifested nuclear shrinkage, condensation and fragmentation. Treatment of A549 cells with MBK resulted in activation of the caspase-3, -8, -9 and cleavage of poly ADP-ribose polymerase (PARP). In the upstream, MBK increased the expressions Bax and Bak, decreased the expression of Bcl-2, and augmented the Bax/Bcl-2 ratio. MBK-induced apoptosis was accompanied by sustained phosphorylation of JNK, p38 MAPK and apoptosis signal-regulating kinase (ASK)-1. These results suggest that MBK induced apoptosis in A549 cells through Bcl-2 family protein-mediated mitochondria/caspase-3 dependent pathway. In addition, MBK increased the activation of ASK-1, which are critical upsteam signals for JNK/p38 MAPK activation in A549 cancer cells.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Wylie, A. H. / 1980 / Cell death: the significance of apoptosis / Int Rev Cytol 68 : 251 ~ 306
[학술지(정기간행물)] - Searle, J. / 1982 / Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance / Pathol Annu 17 (pt 2) : 229 ~ 259
[학술지(정기간행물)] - Im, S. Y. / 1997 / Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression / Eur J Immunol 27 (11) : 2800 ~ 2804
[학술지(정기간행물)] - Byung-Keun Yang / 2009 / Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model / Mycobiology 37 (2) : 128 ~ 132
[학술지(정기간행물)] - Yiu, H.Y. / 2004 / Increasing colorectal cancer incidence rates in Japan / Int J Cancer 109 (5) : 777 ~ 781
[학술지(정기간행물)] - Searle, J. / 1982 / Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance / Pathol Annu 17 (pt 2) : 229 ~ 259
[학술지(정기간행물)] - Im, S. Y. / 1997 / Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression / Eur J Immunol 27 (11) : 2800 ~ 2804
[학술지(정기간행물)] - Byung-Keun Yang / 2009 / Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model / Mycobiology 37 (2) : 128 ~ 132
[학술지(정기간행물)] - Yiu, H.Y. / 2004 / Increasing colorectal cancer incidence rates in Japan / Int J Cancer 109 (5) : 777 ~ 781
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A549세포에서 닥나무 추출물의 미토콘드리아/Caspase 경로를 통한 Apoptosis 유도작용
동의생리병리학회지
2016 .01
-
Inhibitory Effects of Schisandra chinensis Seed Extracts on Breast Cancer
대한의생명과학회지
2025 .03
-
Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Non-small-cell Lung-cancer Cell Line, A549
Journal of Pharmacopuncture
2015 .01
-
Propofol attenuates hydrogenperoxide- induced apoptosis in human umbilical vein endothelial cells via multiple signaling pathways
Korean Journal of Anesthesiology
2015 .01
-
Anticancer Activity of Bispidinone Derivative by Induction of Apoptosis
대한의생명과학회지
2020 .12
-
L-Ascorbic Acid Induces Apoptosis in Human Laryngeal Epidermoid Hep-2 Cells by Modulating the NF-κB/MAPK/Akt Signaling Pathway
International Journal of Oral Biology
2020 .01
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
Gut and Liver
2016 .01
-
Fucoidan Induces Apoptosis in A2058 Cells through ROS-exposed Activation of MAPKs Signaling Pathway
Natural Product Sciences
2020 .09
-
Apoptosis of Human Bladder Cancer Cells by an Ethanolic Extract of Scutellaria Baicalensis GEORGI Via Caspase and MAPK Signaling Pathways
동의생리병리학회지
2016 .01
-
Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells
Journal of Breast Cancer
2015 .01
-
Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
Journal of Veterinary Science
2015 .09
-
Flavonoids from Orostachys Japonicus A. Berger Induces Caspase-dependent Apoptosis at Least Partly through Activation of p38 MAPK Pathway in U937 Human Leukemic Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells
고신대학교 의과대학 학술지
2016 .01
-
Over Expression of BCL2 and Low Expression of Caspase 8 Related to TRAIL Resistance in Brain Cancer Stem Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Lentivirus-Mediated Short-Hairpin RNA Targeting Protein Phosphatase 4 Regulatory Subunit 1 Inhibits Growth in Breast Cancer
Journal of Breast Cancer
2015 .01
-
Orostachys japonicus DW and EtOH Extracts Induce Apoptosis in Cholangiocarcinoma Cell Line SNU-1079
대한한의학회지
2015 .12
-
Apoptotic effect of betulinic acid in FaDu human head and neck squamous cell carcinomas
Oral Biology Research
2024 .09
-
Apoptosis of Human Bladder Cancer Cells by an Ethanolic Extract of Scutellaria Baicalensis GEORGI Via Caspase and MAPK Signaling Pathways
동의생리병리학회지
2016 .04
-
Induction of Human Hepatocellular Carcinoma HepG2 Cell Apoptosis by Naringin
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
A549 폐암세포에서 미토콘드리아 경로를 통한 개똥쑥 추출물의 apoptosis 유도 효과
김보민
,
김근태
,
김은지
외 3명
생명과학회지
2016
.08
ginsenoside Rg3에 의한 B16F10 흑색종 세포의 세포사멸 유도
이슬기
,
김병수
,
남주옥
생명과학회지
2014
.09
봉독이 위암 세포주에 미치는 효과
허경
,
김명호
,
임성우
동의생리병리학회지
2013
.02
대장암세포주에서 적양 추출물의 미토콘드리아/Caspases 경로를 통한 Apoptosis 유도 작용
전병국
,
백순기
,
우원홍
외 1명
동의생리병리학회지
2012
.04
조직시민행동의 영향요인 분석: 공공봉사동기와 조직 내 의사소통을 중심으로
윤선일
,
유두호
지방정부연구
2021
.11
최근 본 자료
댓글(0)
0