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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 310 - 317 (8page)
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Background/Aims: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to document the changes in protein expression involved in tumor growth and suppression.
Methods: Human extrahepatic bile duct cancer cells were cultured. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays were performed to determine the effect of statins on cell proliferation. Apoptosis was measured by a cell death detection enzyme-linked immunosorbent assay and caspase-3 activity assay, and flow cytometry was used to determine the percentage of cells in each phase of the cell cycle. The protein expression of Bax, Bcl-2, insulin-like growth factor 1 (IGF-1) receptor, extracellular signal-regulated kinase 1/2 (ERK1/2), and Akt was measured by Western blot analysis. Results: Simvastatin suppressed cell proliferation by inducing G1 phase cell cycle arrest in bile duct cancer cells. Furthermore, it induced apoptosis via caspase-3 activation, downregulated the expression of the Bcl-2 protein, and enhanced the expression of the Bax protein. Moreover, simvastatin suppressed the expression of the IGF-1 receptor and IGF-1-induced ERK/Akt activation. Conclusions: Simvastatin induces apoptosis in bile duct cancer cells, which suggests that it could be an antineoplastic agent for bile duct cancer.
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참고문헌 (33)
참고문헌 신청
Sirica AE / 2005 / Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy / Hepatology 41:5~15
Jarnagin WR / 2001 / Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma / Ann Surg 234:507~517
Ustundag Y / 2008 / Cholangiocarcinoma: a compact review of the literature / World J Gastroenterol 14:6458~6466
Murakami Y / 2009 / Gemcitabine-based adjuvant chemotherapy improves survival after aggressive surgery for hilar cholangiocarcinoma / J Gastrointest Surg 13:1470~1479
Lee GW / 2006 / Combination chemotherapy with gemcitabine and cisplatin as first-line treatment for immunohistochemically proven cholangiocarcinoma / Am J Clin Oncol 29:127~131
Jarnagin WR / 2001 / Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma / Ann Surg 234:507~517
Ustundag Y / 2008 / Cholangiocarcinoma: a compact review of the literature / World J Gastroenterol 14:6458~6466
Murakami Y / 2009 / Gemcitabine-based adjuvant chemotherapy improves survival after aggressive surgery for hilar cholangiocarcinoma / J Gastrointest Surg 13:1470~1479
Lee GW / 2006 / Combination chemotherapy with gemcitabine and cisplatin as first-line treatment for immunohistochemically proven cholangiocarcinoma / Am J Clin Oncol 29:127~131
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