개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,195 - 1,202 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: The aim of this study was to investigate whether propofol could attenuate hypoxia/reoxygenation-induced apoptosisand autophagy in human renal proximal tubular cells (HK-2) by inhibiting JNK activation. Materials and Methods: HK-2 cells were treated with or without propofol or JNK inhibitor SP600125 for 1 hour and then subjectedto 15 hours of hypoxia and 2 hours of reoxygenation (H/R). Cell viability and LDH release were measured with commercial kits. Cell apoptosis was evaluated by flow cytometry. The expressions of p-JNK, cleaved-caspase-3, Bcl-2, and autophagy markers LC3and p62 were measured by Western blot or immunofluorescence. Results: HK-2 cells exposed to H/R insult showed higher cell injury (detected by increased LDH release and decreased cell viability),increased cell apoptosis index and expression of cleaved-caspase-3, a decrease in the expression of Bcl-2 accompanied byincreased expression of p-JNK and LC3II, and a decrease in expression of p62. All of these alterations were attenuated by propofoltreatment. Similar effects were provoked upon treatment with the JNK inhibitor SP600125. Moreover, the protective effects weremore obvious with the combination of propofol and SP600125. Conclusion: These results suggest that propofol could attenuate hypoxia/reoxygenation induced apoptosis and autophagy inHK-2 cells, probably through inhibiting JNK activation.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Saat TC / 2016 / Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury : lost in translation / J Transl Med 14:20
Chouchani ET / 2016 / A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury / Cell Metab 23:254~263
Hamzawy M / 2019 / 22-oxacalcitriol prevents acute kidney injury via inhibition of apoptosis and enhancement of autophagy / Clin Exp Nephrol 23:43~55
Smith SF / 2019 / Ischemia-reperfusion injury in renal transplantation : 3 key signaling pathways in tubular epithelial cells / Kidney Int 95:50~56
Su M / 2017 / Impact of propofol on renal ischemia/reperfusion endoplasmic reticulum stress / Acta Cir Bras 32:533~539
Chouchani ET / 2016 / A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury / Cell Metab 23:254~263
Hamzawy M / 2019 / 22-oxacalcitriol prevents acute kidney injury via inhibition of apoptosis and enhancement of autophagy / Clin Exp Nephrol 23:43~55
Smith SF / 2019 / Ischemia-reperfusion injury in renal transplantation : 3 key signaling pathways in tubular epithelial cells / Kidney Int 95:50~56
Su M / 2017 / Impact of propofol on renal ischemia/reperfusion endoplasmic reticulum stress / Acta Cir Bras 32:533~539
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Indirubin-3-monoxime Prevents Tumorigenesis in Breast Cancer through Inhibition of JNK1 Activity
대한의생명과학회지
2021 .09
-
Propofol attenuates hydrogenperoxide- induced apoptosis in human umbilical vein endothelial cells via multiple signaling pathways
Korean Journal of Anesthesiology
2015 .01
-
MAPK/JNK-mediated apoptosis and autophagy induction by gossypin HT-29 human colorectal cancer
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells
Cancer Research and Treatment
2015 .01
-
Propofol protects against oxidative-stress-induced COS-7 cell apoptosis by inducing autophagy
Journal of dental anesthesia and pain medicine
2017 .01
-
Propofol protects human keratinocytes from oxidative stress via autophagy expression
Journal of dental anesthesia and pain medicine
2017 .01
-
Antitumor and apoptotic effect of quercetin in human melanoma cells involving JNK/P38 MAPK signaling activation
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Effect and Mechanism Study of Sodium Houttuyfonate on Ventilator-Induced Lung Injury by Inhibiting ROS and Inflammation
Yonsei Medical Journal
2021 .01
-
Acebutolol, a Cardioselective Beta Blocker, Promotes Glucose Uptake in Diabetic Model Cells by Inhibiting JNK-JIP1 Interaction
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Can Cancer Therapy be Achieved by Bridging Apoptosis and Autophagy: a Method Based on microRNA-Dependent Gene Therapy and Phytochemical Targets
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells
Journal of Ginseng Research
2017 .07
-
와송이 인간 백혈병 세포주 THP-1에서 NF-κB 활성 억제와 p38 활성을 통해 세포사멸과 자가포식에 미치는 영향
대한한의학회지
2019 .06
-
Alpha-lipoic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced cell injury by inhibiting autophagy and apoptosis
International Journal of Oral Biology
2021 .01
-
Remifentanil induces autophagy and prevents hydrogen peroxide-induced apoptosis in Cos-7 cells
Journal of dental anesthesia and pain medicine
2016 .01
-
Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect
The Korean Journal of Physiology & Pharmacology
2021 .09
-
L-Ascorbic Acid Induces Apoptosis in Human Laryngeal Epidermoid Hep-2 Cells by Modulating the NF-κB/MAPK/Akt Signaling Pathway
International Journal of Oral Biology
2020 .01
-
Delphinidin enhances radio-therapeutic effects via autophagy induction and JNK/MAPK pathway activation in non-small cell lung cancer
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Tumor hypoxia and reoxygenation: the yin and yang for radiotherapy
Radiation oncology journal : ROJ
2016 .01
-
A549세포에서 닥나무 추출물의 미토콘드리아/Caspase 경로를 통한 Apoptosis 유도작용
동의생리병리학회지
2016 .01
-
A549세포에서 닥나무 추출물의 미토콘드리아/Caspase 경로를 통한 Apoptosis 유도작용
동의생리병리학회지
2016 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0