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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 459 - 470 (12page)
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이 논문의 연구 히스토리 (4)
2015
Transcriptome wide discovery of selected role players in acute phase response of black rockfish (Sebastes schlegelii) and antioxidative defense of rock bream (Oplegnathus fasciatus), revealing their putative significance in host immune responses
Don Anushka Sanda
,
uwan Elvitigala
해양생명
2015.01
학위논문
Molecular profile and expressional modulation of a Toll like receptor-1 homolog from rock bream (Oplegnathus fasciatus)
Don Anushka Sanda
,
uwan Elvitigala
,
H.K.A. P
외 6명
Genes & Genomics
2015.01
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초록· 키워드
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Toll-like receptors (TLRs) are well-described pattern recognition receptors that recognize different pathogen-associated molecular patterns (PAMPs) to activate innate immune responses. TLR1 forms a heterodimer with TLR2 that works to identify PAMPs including bacterial components. In the present study, we identified a TLR1 homolog from rock bream Oplegnathus fasciatus (RbTLR1) and characterized it at the genomic level. The complete coding sequence of RbTLR1 was 2406 bp in length and encoded an 802 amino acid protein possessing a calculated molecular mass of 90.7 kDa and typical TLR domain architecture. A single exon spanned the genomic length (2931 bp) of RbTLR1. Phylogenetic analysis showed a close evolutionary relationship between RbTLR1 and its fish orthologs. Using quantitative real time polymerase chain reaction, we detected RbTLR1 mRNA in all the tissues examined, suggesting its merely universal tissue expression. RbTLR1 was expressed strongly in the spleen, kidney, and liver. Following immune stimulation by bacterial pathogens and mitogens, RbTLR1 transcript levels were elevated at various time points post stimulation.
Moreover, injection of a viral stimulant, polyinosinic: polycytidylic acid, and rock bream iridovirus altered the basal transcription of RbTLR1. Collectively, these data showed that RbTLR1 is transcriptionally regulated in response to bacterial and viral stimulation, suggesting its putative importance in host immune defense.
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
Anderson KV / 2000 / Toll signaling pathways in the innate immune response / Curr Opin Immunol 12:13~19
Arnold K / 2006 / The SWISSMODEL workspace: a web-based environment for protein structure homology modelling / Bioinformatics 22:195~201
Bell JK / 2003 / Leucine-rich repeats and pathogen recognition in Tolllike receptors / Trends Immunol 24:528~533
Boehme KW / 2006 / Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells / J Immunol 177:7094~7102
Anderson KV / 2000 / Toll signaling pathways in the innate immune response / Curr Opin Immunol 12:13~19
Arnold K / 2006 / The SWISSMODEL workspace: a web-based environment for protein structure homology modelling / Bioinformatics 22:195~201
Bell JK / 2003 / Leucine-rich repeats and pathogen recognition in Tolllike receptors / Trends Immunol 24:528~533
Boehme KW / 2006 / Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells / J Immunol 177:7094~7102
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