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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1,259 - 1,268 (10page)
- DOI
- 10.1007/s13258-021-01149-1
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초록· 키워드
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Background Rock bream iridovirus (RBIV) is one of the most dangerous pathogens that causes the highest mortality in the aquaculture of rock bream (Oplegnathus fasciatus). Even though RBIV infection leads to huge economic loss, proteome studies on RBIV-infected rock bream have not been conducted to provide information about the diferential protein expression pattern by the host protection system.
Objective The purpose of this study was to investigate the protein expression patterns in spleens of rock bream olive after infection by RBIV or mixed infection by RBIV and bacteria.
Methods Depending on the infection intensity and sampling time point, fsh were divided into fve groups: uninfected healthy fsh at week 0 as the control (0C), heavily infected fsh at week 0 (0H), heavily mixed RBIV and bacterial infected fsh at week 0 (0MH), uninfected healthy fsh at week 3 (3C), and lightly infected fsh at week 3 (3L). Proteins were extracted from the spleens of infected rock bream. We used 2-DE analysis with LC?MS/MS to investigate proteome changes in infected rock bream.
Results The results of the LC?MS/MS analyses showed diferent protein expression profles after infection. Proteins related to oxygen transport and energy generation, such as hemoglobin, beta-globin, and ATP synthase, were mostly expressed in the infected spleen. Whereas proteins involved in structure and cell movement, such as tubulin, myosin, actin binding proteins, and intermediate flament proteins, were down-regulated in the infected spleens. The protein expression profles between infection by RBIV and mixed infection by RBIV and bacteria showed similar patterns.
Conclusions Our results indicated that infection by RBIV or mixed infection by RBIV and bacteria triggered energy generation and oxygen-transport, but cell migration and constructional changes in the spleen were extremely decreased.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cha IS / 2012 / Cathepsins in the kidney of olive founder, Paralichthys olivaceus, and their responses to bacterial infection / Dev Comp Immunol 38:538~544
Cha IS / 2012 / Kidney proteome responses in the teleost fish Paralichthys olivaceus indicate a putative immune response against Streptococcus parauberis / J Proteom 75:5166~5175
de Moerloose P / 2013 / Congenital fbrinogen disorders : an update / Semin Thromb Hemost 39:585~595
Do JW / 2004 / Complete genomic DNA sequence of rock bream iridovirus / Virology 325:351~363
Elvitigala DA / 2012 / Caspase 3 from rock bream(Oplegnathus fasciatus) : genomic characterization and transcriptional profling upon bacterial and viral inductions / Fish Shellfsh Immunol 33:99~110
Cha IS / 2012 / Kidney proteome responses in the teleost fish Paralichthys olivaceus indicate a putative immune response against Streptococcus parauberis / J Proteom 75:5166~5175
de Moerloose P / 2013 / Congenital fbrinogen disorders : an update / Semin Thromb Hemost 39:585~595
Do JW / 2004 / Complete genomic DNA sequence of rock bream iridovirus / Virology 325:351~363
Elvitigala DA / 2012 / Caspase 3 from rock bream(Oplegnathus fasciatus) : genomic characterization and transcriptional profling upon bacterial and viral inductions / Fish Shellfsh Immunol 33:99~110
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