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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 419 - 427 (9page)
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Deer antlers are the only mammalian appendages subject to an annual cycle of epimorphic regeneration.
Within the rapid-growth stage, they display the fastest cartilage development in the animal kingdom. To identify microRNA (miRNA) profiling in red deer (Cervus elaphus) antler cartilage, we applied deep sequencing technology to a small RNA library constructed from pooled cartilage (three antlers from three individuals). We generated 9,520,645 mappable reads with a size distribution of between 15 and 30 nucleotides (miRNAs of 18 nucleotides were the most abundant group: 31 %). Bioinformatics data mining revealed 399 miRNAs in antler cartilage, of which 345 were highly conserved and expressed in 25 other mammals, including the cattle (Bos taurus) and in humans (Homo sapiens). The remaining 54 miRNAs we identified were novel and likely to be antler-cartilage specific, but were expressed at low levels. The identification of these known and newly identified miRNAs in antler cartilage significantly enhances our understanding of the miRNA profiling of regenerating antler cartilage. Further studies are necessary to better understand miRNAs-regulated antlerogenesis.
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등록된 정보가 없습니다.
참고문헌 (63)
참고문헌 신청
Allen SP / 2002 / A role for retinoic acid in regulating the regeneration of deer antlers / Dev Biol 251:409~423
Ambady S / 2012 / Identification of novel MicroRNAs in Xenopus laevis metaphase II arrested eggs / Genesis 50:286~299
Ambros V / 2001 / microRNAs: tiny regulators with great potential / Cell 107:823~826
Ambros V / 2003 / A uniform system for microRNA annotation / RNA 9:277~279
Banks JW / 1983 / Light microscopic studies of the ossification process in developing antlers / Antler Development in cervidea: a proceedings of the first international symposium of the Caesar Kleberg Wildlife Research Institute, College of Agriculture, Texas A&I University :231~260
Ambady S / 2012 / Identification of novel MicroRNAs in Xenopus laevis metaphase II arrested eggs / Genesis 50:286~299
Ambros V / 2001 / microRNAs: tiny regulators with great potential / Cell 107:823~826
Ambros V / 2003 / A uniform system for microRNA annotation / RNA 9:277~279
Banks JW / 1983 / Light microscopic studies of the ossification process in developing antlers / Antler Development in cervidea: a proceedings of the first international symposium of the Caesar Kleberg Wildlife Research Institute, College of Agriculture, Texas A&I University :231~260
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