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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 223 - 229 (7page)
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Role of DNA methylation has been implicated indiverse biological processes such as cell proliferation, survivaland reprogramming. Although the mechanism for DNAmethylation has been relatively well characterized, proteinsresponsible for DNA demethylation had been elusive untilrecently. In 2009, Tahiliani et al. demonstrated that human tento-eleven translocation (TET) proteins can convert 5-methylcytosine(5mC) into 5-hydroxymethylcytosine (5hmC). Subsequentstudies also revealed that 5hmCcan be further oxidizedinto 5-formylcytosine and 5-carboxycytosine by TET proteins.
So far, evidence from numerous studies suggests that TETmediated5mC oxidation plays important roles in transcriptionalregulation, development and cellular reprogrammingincluding in vitro iPS cell generation and in vivo germ cellreprogramming. Among them, recent progress in elucidatingTET protein function and significance of 5mC oxidativederivatives in germ cell biologywill be discussed in this review.
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참고문헌 (65)
참고문헌 신청
Bian C / 2014 / PGC7 suppresses TET3 for protecting DNA methylation / Nucleic Acids Res 42:2893~2905
Bonnefoy E / 2007 / The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization / PLoS Genet 3:1991~2006
Carone B / 2014 / High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm / Dev Cell 30:11~22
Cliffe L / 2009 / JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes / Nucleic Acids Res 37:1452~1462
Dawlaty M / 2011 / Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development / Cell Stem Cell 9:166~175
Bonnefoy E / 2007 / The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization / PLoS Genet 3:1991~2006
Carone B / 2014 / High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm / Dev Cell 30:11~22
Cliffe L / 2009 / JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes / Nucleic Acids Res 37:1452~1462
Dawlaty M / 2011 / Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development / Cell Stem Cell 9:166~175
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