지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 552 - 558 (7page)
이용수
초록· 키워드
오류제보하기
Temporomandibular joint (TMJ) disorder is clinically important because of its prevalence, chronicity, and therapy-refractoriness of the pain. In this study, we investigated the effect of infliximab in a mouse model of TMJ pain using a specially-engineered transducer for evaluating the changes in bite force (BF). The mice were randomly divided into three groups (7 mice per group): the control group, the complete Freund’s adjuvant (CFA) group, and the infliximab group. BF was measured at day 0 (baseline BF). After measuring the baseline BF, CFA or incomplete Freund’s adjuvant was injected into both TMJs and then the changes in BF were measured at days 1, 3, 5, 7, 9, and 13 after the TMJ injection. For measuring the BF, we used a custom-built BF transducer. Control, CFA, and infliximab groups showed similar baseline BF at day 0. From day 1, a significant reduction in BF was observed in the CFA group, and this reduction in BF was statistically significant compared to that in the control group (P < 0.05). This reduction in BF was maintained until day 7, and BF started to recover gradually from day 9. In the infliximab group also, the reduction in BF was observed on day 1, and this reduction was maintained until day 7. However, the degree of reduction in BF was less remarkable compared to that in the CFA group. The reduction in BF caused by injection of CFA into the TMJ could be partially alleviated by the injection of anti-tumor necrosis factor alpha, infliximab.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Turman JE Jr / 2007 / The development of mastication in rodents : from neurons to behaviors / Arch Oral Biol 52:313~316
Yamada Y / 2005 / Coordination of cranial motoneurons during mastication / Respir Physiol Neurobiol 147:177~189
Westberg KG / 2011 / The trigeminal circuits responsible for chewing / Int Rev Neurobiol 97:77~98
Cadden SW / 2009 / Mastication and swallowing: 2. control / Dent Update 36:390~392
Marquezin MC / 2013 / Assessment of masticatory performance, bite force, orthodontic treatment need and orofacial dysfunction in children and adolescents / Arch Oral Biol 58:286~292
Yamada Y / 2005 / Coordination of cranial motoneurons during mastication / Respir Physiol Neurobiol 147:177~189
Westberg KG / 2011 / The trigeminal circuits responsible for chewing / Int Rev Neurobiol 97:77~98
Cadden SW / 2009 / Mastication and swallowing: 2. control / Dent Update 36:390~392
Marquezin MC / 2013 / Assessment of masticatory performance, bite force, orthodontic treatment need and orofacial dysfunction in children and adolescents / Arch Oral Biol 58:286~292
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