Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella

Bian-hua Zhou; Li-li Liu; Jeffrey Liu; Fu-wei Yuan; Er-jie Tian; Hong-wei Wang

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자료유형: 학술저널

저자정보: Bian-hua Zhou (Henan University of Science and Technology) Li-li Liu (Henan University of Science and Technology) Jeffrey Liu (University of California) Fu-wei Yuan (Henan University of Science and Technology) Er-jie Tian (Henan University of Science and Technology) Hong-wei Wang (Henan University of Science and Technology)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.53 No.6

발행연도: 2015.12

수록면: 675 - 682 (8page)

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The effects of diclazuril on the bursa of Fabricius (BF) structure and secretory IgA (SIgA) expression in chickens infected with Eimeria tenella were examined. The morphology of the BF was observed by hematoxylin and eosin staining, while ultrastructural changes were monitored by transmission electron microscopy. E. tenella infection caused the BF cell volumes to decrease, irregularly arranged, as well as, enlargement of the intercellular space. Diclazuril treatment alleviated the physical signs of damages associated with E. tenella infection. The SIgA expression in BF was analyzed by immunohistochemistry technique. The SIgA expression increased significantly by 350.4% (P＜0.01) after E. tenella infection compared to the normal control group. With the treatment of diclazuril, the SIgA was relatively fewer in the cortex, and the expression level was significantly decreased by 46.7% (P＜0.01) compared with the infected and untreated group. In conclusion, E. tenella infection in chickens induced obvious harmful changes in BF morphological structure and stimulated the expression of SIgA in the BF. Diclazuril treatment effectively alleviated the morphological changes. This result demonstrates a method to develop an immunological strategy in coccidiosis control.

#Eimeria tenella #diclazuril #bursa of Fabricius (BF) #secretory immunoglobulin A (SIgA) #ultrastructure #chicken

참고문헌 (42)

참고문헌 신청

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[학술지(정기간행물)] - Haritova AM / 2012 / Enhanced expression of IL-10 in contrast to IL-12B mRNA in poultry with experimental coccidiosis / Exp Parasitol 132 : 378 ~ 382

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