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논문 기본 정보

자료유형
학술저널
저자정보
Hye-Jin Lee (Department of Pharmacology Korea University College of Medicine Seoul 02841 KoreaBK21 Graduate Prog) Bo-Yeong Jin (Department of Pharmacology Korea University College of Medicine Seoul 02841 KoreaBK21 Graduate Prog) Mi-Rae Park (Department of Pharmacology Korea University College of Medicine Seoul 02841 KoreaBK21 Graduate Prog) Kwan Sik Seo (Department of Rehabilitation Medicine Seoul National University Hospital Seoul 03080 Korea) Yong Taek Jeong (Department of Pharmacology Korea University College of Medicine Seoul 02841 KoreaBK21 Graduate Prog) Sang-Hyun Choi (Department of Pharmacology Korea University College of Medicine Seoul 02841 Korea) Dong-Hoon Kim (Department of Pharmacology Korea University College of Medicine Seoul 02841 KoreaBK21 Graduate Prog)
저널정보
대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제4호
발행연도
2021.1
수록면
355 - 363 (9page)

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Dynamic changes in adipose tissue blood flow (ATBF) with nutritional status play a role in the regulation of metabolic and endocrine functions. Activation of the sympathetic nervous system via ?-adrenergic receptors (?-AR) contributes to the control of postprandial enhancement of ATBF. Herein, we sought to identify the role of each ?-AR subtype in the regulation of ATBF in mice. We monitored the changes in visceral epididymal ATBF (VAT BF), induced by local infusion of dobutamine, salbutamol, and CL316,243 (a selective ?1-, ?2-, and ?3-AR agonist, respectively) into VAT of lean CD-1 mice and global adipose triglyceride lipase (ATGL) knockout (KO) mice, using laser Doppler flowmetry. Administration of CL316,243, known to promote lipolysis in adipocytes, significantly increased VAT BF of CD-1 mice to a greater extent compared to that of the vehicle, whereas administration of dobutamine or salbutamol did not produce significant differences in VAT BF. The increase in VAT BF induced by ?3-AR stimulation disappeared in ATGL KO mice as opposed to their wild-type (WT) littermates, implying a role of ATGL-mediated lipolysis in the regulation of VAT BF. Different vascular reactivities occurred despite no significant differences in vessel density and adiposity between the groups. Additionally, the expression levels of the angiogenesis-related genes were significantly higher in VAT of ATGL KO mice than in that of WT, implicating an association of ATBF responsiveness with angiogenic activity in VAT. Our findings suggest a potential role of ?3-AR signaling in the regulation of VAT BF via ATGL-mediated lipolysis in mice
#Adipose tissue blood flow #Adipose triglyceride lipase #Beta adrenergic receptors #Lipolysis #Vasculature

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참고문헌 (37)

참고문헌 신청
Cao Y / 2010 / Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases / Nat Rev Drug Discov 9:107~115 google schola Goossens GH / 2011 / Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation / Circulation 124:67~76 google schola Ye J / 2009 / Emerging role of adipose tissue hypoxia in obesity and insulin resistance / Int J Obes(Lond) 33:54~66 google schola Unamuno X / 2018 / Adipokine dysregulation and adipose tissue inflammation in human obesity / Eur J Clin Invest 48:e12997 google schola Ye J / 2007 / Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice / Am J Physiol Endocrinol Metab. 293:E1118~E1128 google schola

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