지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 56 - 68 (13page)
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초록· 키워드
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Background/Aims: Mucosal healing (MH) of distal lesions in ulcerative colitis (UC) has recently been confirmed with budesonide 2-mg foam (BF) treatment in 2 clinical trials; however, few studies have investigated the predictive factors for complete MH. Methods: We conducted a post hoc analysis using pooled data from phase II and III clinical trials evaluating the efficacy and safety of BF for UC. Additionally, we analyzed the relationships between complete MH and baseline factors and clinical symptoms from baseline to week 6. Results: Among the 291 Japanese patients from the 2 pooled clinical studies, 119 patients in the BF twice a day group and 117 in the placebo group were included in the full analysis set. The proportion of patients with a rectal bleeding (RB) subscore of 0 was significantly higher in the BF group than in the placebo group after a 5-day treatment (P<0.05). After a 2-day treatment, significantly more patients in the BF group had a stool frequency (SF) subscore of 0 than patients in the placebo group (P<0.05). Multivariate analysis showed that complete MH at week 6 was influenced by baseline SF subscore and 5-aminosalicylic acid (5-ASA) enema or suppository use (P=0.0086 and P=0.0015, respectively). The relationship between complete MH at week 6 and RB subscore after week 2 was also confirmed. Conclusions: Normal SF at baseline, history of 5-ASA topical product use, and elimination of RB after week 2 are suggested predictors of complete MH at week 6 with twice-daily BF treatment.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Harbord M / 2017 / Third European evidence-based consensus on diagnosis and management of ulcerative colitis. part 2: current management / J Crohns Colitis 11:769~784
Ko CW / 2019 / AGA clinical practice guidelines on the management of mild-to-moderate ulcerative colitis / Gastroenterology 156:748~764
Brunner M / 2005 / Colonic spread and serum pharmacokinetics of budesonide foam in patients with mildly to moderately active ulcerative colitis / Aliment Pharmacol Ther 22:463~470
Hochhaus G / 1993 / Glucocorticoid therapy in chronic inflammatory bowel disease: from basic principles to rational therapy / Kluwer :61~79
Brattsand R / 1982 / Influence of 16 alpha, 17 alpha-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids / J Steroid Biochem 16:779~786
Ko CW / 2019 / AGA clinical practice guidelines on the management of mild-to-moderate ulcerative colitis / Gastroenterology 156:748~764
Brunner M / 2005 / Colonic spread and serum pharmacokinetics of budesonide foam in patients with mildly to moderately active ulcerative colitis / Aliment Pharmacol Ther 22:463~470
Hochhaus G / 1993 / Glucocorticoid therapy in chronic inflammatory bowel disease: from basic principles to rational therapy / Kluwer :61~79
Brattsand R / 1982 / Influence of 16 alpha, 17 alpha-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids / J Steroid Biochem 16:779~786
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