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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 533 - 541 (9page)
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Peroxisome proliferator-activated receptor gamma (PPAR-γ), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. Recent studies have demonstrated that PPAR-γ ligands are anti-tumorigenic in prostate cancer due to anti-proliferative and pro-differentiation effects. The aim of this study was to validate PPAR-γ expression in malignant and benign prostate tissues by immunohistochemistry and quantitative real-time polymerase chain reaction (PCR). A total of 730 prostatic adenocarcinomas (PCAs) including 63 whole sections from radical prostatectomy specimens and tissue microarrays containing 667 PCAs were subject to immunostaining for two PPAR-γ antibodies. Twenty-five benign prostate tissues and PCAs were selected for investigating mRNA expression by quantitative real-time PCR. 10.7% of PCAs (78/730) showed cytoplasmic immunoreactivity of PPAR-γ and no nuclear immunoreactivity was noted in PCAs. Most benign prostatic glands showed negative immunoreactivity of PPAR-γ except for variable weak cytoplasmic staining in some glands.
Nuclear immunoreactivity of PPAR-γ was noted some central zone and verumontanum mucosal epithelium. The constitutive PPAR-γ mRNA showed significantly lower level in PCAs compared to that in the benign tissues. There was no difference of PPAR-γ mRNA expression between low (≤ 7) and high (> 7) Gleason score groups. There was no association of PPAR-γ mRNA level or cytoplasmic immunostaining with Gleason grade or pathologic stage. Our study supported the evidence of extra‑nuclear localization and nongenomic actions of PPAR-γ. Further studies are needed to assess the functional role of PPAR-γ and to validate its therapeutic implication in prostate cancer.
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참고문헌 (37)
참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Cao Y / 2011 / Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis / Cancer Prev Res (Phila) 4:486~501
Leitzmann MF / 2012 / Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates / Clin Epidemiol 4:1~11
Helpap B / 2013 / The heterogeneous Gleason 7 carcinoma of the prostate : analyses of low and high grade(risk)carcinomas with criteria of the International Society of Urological Pathology(ISUP) / Pathol Res Pract 209:190~194
Thompson I / 2007 / Guideline for the management of clinically localized prostate cancer: 2007 update / J Urol 177:2106~2131
Cao Y / 2011 / Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis / Cancer Prev Res (Phila) 4:486~501
Leitzmann MF / 2012 / Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates / Clin Epidemiol 4:1~11
Helpap B / 2013 / The heterogeneous Gleason 7 carcinoma of the prostate : analyses of low and high grade(risk)carcinomas with criteria of the International Society of Urological Pathology(ISUP) / Pathol Res Pract 209:190~194
Thompson I / 2007 / Guideline for the management of clinically localized prostate cancer: 2007 update / J Urol 177:2106~2131
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