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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 106 - 106 (1page)
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The Tox21 high throughput screening(HTS) data has the advantage of high-speed screening, but only the verification of chemicals through three repeated experiments doesn’t provide sufficient information on chemicals. Human peroxisome proliferator-activated receptor gamma(PPARγ) showed lower reliability compared to other receptors in three replicates tested in the Tox21 10k library project. PPARγ is well known as a regulator of adipogenesis and insulin sensitivity. In this study, the in vitro data of PPARγ presented in Tox21 high-throughput screening (HTS) was verified through orthogonal assay, and the application of the in silico model was investigated. We constructed a PPARγ-GAL4-UAS system-based reporter gene assay in CV-1 cells for comparison with the results of HEK293 cells used in the Tox21 HTS system. 33 chemicals for agonist and ... 전체 초록 보기
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