Peroxisome Proliferator-Activated Receptor-Gamma Pro12Ala Polymorphism Could be a Risk Factor for Gastric Cancer

Zhao, Jing; Zhi, Zheng; Song, Guangyao; Wang, Juan; Wang, Chao; Ma, Huijuan; Yu, Xian; Sui, Aixia; Zhang, Hongtao

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자료유형: 학술저널

저자정보: Zhao, Jing (The First Department of Oncology, Hebei General Hospital) Zhi, Zheng (The First Department of Oncology, Hebei General Hospital) Song, Guangyao (Department of Endocrinology, Hebei General Hospital) Wang, Juan (The First Department of Oncology, Hebei General Hospital) Wang, Chao (Department of Clinical Research Center, Hebei General Hospital) Ma, Huijuan (Department of Endocrinology, Hebei General Hospital) Yu, Xian (Department of Endocrinology, Hebei General Hospital) Sui, Aixia (The First Department of Oncology, Hebei General Hospital) Zhang, Hongtao (The First Department of Oncology, Hebei General Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제6호

발행연도: 2015.1

수록면: 2,333 - 2,340 (8page)

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Background: Due to the strong inhibitory effects of $PPAR{\gamma}$ gene on the growth of cancer cells, the role of Pro12Ala polymorphism in $PPAR{\gamma}$ gene has been extensively investigated in cancer recently. However, the results were inconsistent according to cancer type. The aim of this study was to comprehensively evaluate the $PPAR{\gamma}$ Pro12Ala polymorphism and gastric cancer susceptibility. Materials and Methods: Search strategies were conducted in Pubmed, Medline (Ovid), Chinese biomedical database (CBM), China national knowledge infrastructure (CNKI), VIP, and Wanfang database, covering all publications, with the last search up to November 01, 2014. The strength of association between $PPAR{\gamma}$ Pro12Ala polymorphism and gastric cancer risk was assessed by OR with 95%CI. Results: A total of 546 cases and 827 controls in 5 case-control studies were included in this meta-analysis. The results indicated that the variant G allele carriers (CG+GG) had a 2.31 times higher risk for gastric cancer when compared with the homozygote CC (odds ratio (OR)=2.31, 95% confidence interval (CI)=1.67-3.21 for CG+GG vs. CC). In the subgroup analysis by ethnicity, significantly elevated risks were both found in Asians (OR=2.56, 95% CI=1.42-4.64) and Caucasians (OR=2.20, 95% CI=1.48-3.25). Similarly, in the subgroup analysis by H. pylori status, a significantly increased risk was identified in H. pylori (+) populations (OR=3.68, 95%CI=2.07-6.52), but not in H. pylori(-) populations (OR=1.17, 95%CI=0.58-2.39). Conclusions: This pooled analysis suggested that the $PPAR{\gamma}$ Pro12Ala polymorphism could be an independent predictive risk factor for gastric cancer especially in H. pylori infected populations in Asians and Caucasians. Nevertheless, prospectively designed cohort studies are needed to further investigate gene-gene and gene-environment interactions to confirm the combined effects of $PPAR{\gamma}$ Pro12Ala polymorphisms and H. pylori infection on gastric cancer risk.

#Peroxisome proliferator-activated receptor ${gamma} #PPAR{gamma})$ #polymorphism #gastric cancer

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