지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 28 - 36 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling related to various processes such as morphogenesis, angiogenesis, tissue repair, invasion, and metastasis. We investigated the effects of PPARγ on MMP expression and invasion in breast cancer cells. Methods: MCF-7 cells were cultured and then cell viability was monitored in an MTT assay. Western blotting, gelatin zymography, real-time polymerase chain reaction, and luciferase assays were performed to investigate the effect of the synthetic PPARγ ligand troglitazone on MMP expression. Transcription factor DNA binding was analyzed by electrophoretic mobility shift assay. A Matrigel invasion assay was used to assess the effects of troglitazone on MCF-7 cells. Results: Troglitazone did not affect MCF-7 cell viability. 12-O-tetradecanoylphorbol-13-acetate (TPA) induced MMP-9 expression and invasion in MCF-7 cell. However, these effects were decreased by troglitazone. TPA increased nuclear factor κB and activator protein-1 DNA binding, while troglitazone inhibited these effects. The selective PPARγ antagonist GW9662 reversed MMP-9 inhibition by troglitazone in TPA-treated MCF-7 cells. Conclusion: Troglitazone inhibited nuclear factor κB and activator protein-1-mediated MMP-9 expression and invasion of MCF-7 cells through a PPARγ-dependent mechanism.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Takaoka M / 2003 / Heparanase expression correlates with invasion and poor prognosis in gastric cancers / Lab Invest 83:613~622
Wang L / 2010 / Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells / Cancer Lett 297:42~48
Yao J / 2001 / Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells / Oncogene 20:8066~8074
Liacini A / 2002 / Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes / Matrix Biol 21:251~262
Takaoka M / 2003 / Heparanase expression correlates with invasion and poor prognosis in gastric cancers / Lab Invest 83:613~622
Wang L / 2010 / Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells / Cancer Lett 297:42~48
Yao J / 2001 / Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells / Oncogene 20:8066~8074
Liacini A / 2002 / Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes / Matrix Biol 21:251~262
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy
Yonsei Medical Journal
2016 .01
-
Peroxisome Proliferator-Activated Recetor γ Agonist Troglitazone Suppresses Cell Migration and Invasion by Regulating Glutathione Peroxidase 3 Expression and Epithelial-Mesenchymal Transitions in PC-3 Human Prostate Cancer Cells
한국실험동물학회 학술발표대회 논문집
2016 .02
-
PPARγ에 의해 유도된 지방세포생성에 대한 테스토스테론의 억제효과
Journal of Obesity & Metabolic Syndrome
2016 .01
-
Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells
Journal of Breast Cancer
2015 .01
-
Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
International Journal of Oral Biology
2015 .01
-
Comparative Evaluation of Silibinin Effects on Cell Cycling and Apoptosis in Human Breast Cancer MCF-7 and T47D Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
참옻 추출물의 MCF-7 인체 유방암 세포에서 증식 억제효과
대한한의학방제학회지
2016 .01
-
Pleiotropic Roles of Metalloproteinases in Hematological Malignancies: an Update
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Cellular Effects of Troglitazone on YD15 Tongue Carcinoma Cells
International Journal of Oral Biology
2016 .01
-
Anti-metastatic Effect of Natural Product-motivated Synthetic PPAR-γ Ligands
Natural Product Sciences
2022 .06
-
Effects of Metformin on Cell Kinetic Parameters of MCF-7 Breast Cancer Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Expression of Peroxisome Proliferator Activated Receptor gamma in Prostatic Adenocarcinoma
Journal of Korean Medical Science
2015 .01
-
Tetrabromobisphenol A Induces MMP-9 Expression via NADPH Oxidase and the activation of ROS, MAPK, and Akt Pathways in Human Breast Cancer MCF-7 Cells
Toxicological Research
2019 .01
-
MicroRNA-29 Family Suppresses the Invasion of HT1080 Human Fibrosarcoma Cells by Regulating Matrix Metalloproteinase 2 Expression
전남의대학술지
2017 .01
-
Matrix Metalloproteinase-9 -1562T Allele and its Combination with MMP-2 -735 C Allele are Risk Factors for Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Imidazole Antifungal Drugs Inhibit the Cell Proliferation and Invasion of Human Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Characteristics of Expression of Matrix Metalloproteinases (MMP-2 and MMP-9) in Glottic Squamous Cell Carcinoma and Benign Vocal Fold Lesions
Clinical and Experimental Otorhinolaryngology
2015 .01
-
Lobeglitazone, A Peroxisome Proliferator-Activated Receptor-Gamma Agonist, Inhibits Papillary Thyroid Cancer Cell Migration and Invasion by Suppressing p38 MAPK Signaling Pathway
Endocrinology and Metabolism
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0