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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 54 - 59 (6page)
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The aim of this study was to investigate relationships between acute exacerbation andForced Expiratory Volume 1 second (FEV1) improvement after treatment with combinedlong-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronicobstructive pulmonary disease (COPD). A total of 137 COPD patients were classified asresponders or nonresponders according to FEV1 improvement after 3 months of LABA/ICStreatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these twosubgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%)were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbationsoccurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in thenonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was asignificant prognostic factor for fewer acute exacerbations in a multivariate Coxproportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walkdistance, body mass index, exacerbation history in the previous year, and dyspnea scale.
Three-month treatment response to LABA/ICS might be a prognostic factor for theoccurrence of acute exacerbation in COPD patients.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Lee JH / 2010 / Responses to inhaled long-acting beta-agonist and corticosteroid according to COPD subtype / Respir Med 104:542~549
Donohue JF / 2011 / Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease / Int J Chron Obstruct Pulmon Dis 6:35~45
Miles MC / 2012 / Optimum bronchodilator combinations in chronic obstructive pulmonary disease: what is the current evidence? / Drugs 72:301~308
Lee JS / 2011 / Different therapeutic responses in chronic obstructive pulmonary disease subgroups / Int J Tuberc Lung Dis 15:1104~1110
Alvarez-Gutiérrez FJ / 2007 / Impact of chronic obstructive pulmonary disease on activities of daily living: results of the EIME multicenter study / Arch Bronconeumol 43:64~72
Donohue JF / 2011 / Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease / Int J Chron Obstruct Pulmon Dis 6:35~45
Miles MC / 2012 / Optimum bronchodilator combinations in chronic obstructive pulmonary disease: what is the current evidence? / Drugs 72:301~308
Lee JS / 2011 / Different therapeutic responses in chronic obstructive pulmonary disease subgroups / Int J Tuberc Lung Dis 15:1104~1110
Alvarez-Gutiérrez FJ / 2007 / Impact of chronic obstructive pulmonary disease on activities of daily living: results of the EIME multicenter study / Arch Bronconeumol 43:64~72
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