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논문 기본 정보

자료유형
학술저널
저자정보
최용준 (연세대학교) 김창화 (연세대학교) 이재욱 (연세대학교) 변민광 (연세대학교) 조재화 (연세대학교) 박혜정 (연세대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제63권 제7호
발행연도
2022.7
수록면
603 - 610 (8page)
DOI
10.3349/ymj.2022.63.7.603

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Purpose: Currently, there are multiple options for the pharmacological treatment of asthma. This study aimed to compare the ef fects of different asthma medications on exacerbation in a real-world setting. Materials and Methods: We retrospectively reviewed electronic medical records of asthma patients who visited the hospital fromNovember 1, 2016 to October 31, 2019. The number of asthma exacerbations requiring administration of systemic steroids wasthe primary outcome. A time-varying Cox regression analysis was used to reflect the real-world setting: variable usage times, dis continuation, and switching of medication. Results: Among 937 patients with asthma, 228 (24.3%) experienced asthma exacerbation during the study period. Asthma exacer bation was observed in patients using short-acting β2-agonists (SABA) alone (50.4% vs. 28.6%, p<0.001) as well as in patients not us ing inhaled corticosteroids (ICS) (58.8% vs. 40.3%, p<0.001), long-acting β2-agonists (LABA) (54.8% vs. 36.1%, p<0.001), and leukot riene receptor antagonists (71.5% vs. 50.8%, p<0.001). A time-varying Cox regression analysis of asthma exacerbations according tothe duration of asthma medication showed that SABA alone increased the risk of asthma exacerbation [hazard ratio (HR), 1.834;95% confidence interval (CI), 1.299–2.588; p=0.001], whereas ICS-LABA decreased the risk (HR, 0.733; 95% CI, 0.538–0.997;p=0.048). However, in the subgroup analysis according to medication type, specific ingredients showed no significant differences. Conclusion: In the real world, asthma medications affect asthma exacerbation variably according to the medication type.

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