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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 85 - 89 (5page)
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초록· 키워드
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Background: Although chronic obstructive pulmonary disease is a known cause of secondary polycythemia with elevated erythropoietic demands in response to hypoxemia, anemia is relatively common in patients with chronic obstructive pulmonary disease and is related to increased mortality. However, little is currently known about the relationship between various iron parameters and disease severity in chronic obstructive pulmonary disease pa-tients.Methods: Data from the fifth Korean National Health and Nutrition Examination Survey, a population-based epi-demiologic survey conducted in 2010–2012, were used. A total of 1,129 patients with chronic obstructive pulmo-nary disease were examined to reveal the associations between the forced expiratory volume in 1 second (FEV1) and hemoglobin and iron parameters, including serum iron, ferritin, total iron binding capacity, and transferrin saturation, using Spearman correlations and multiple linear regression analyses.Results: The FEV1 was positively correlated with serum hemoglobin (g=0.37, P<0.001), iron (g=0.20, P<0.001), transferrin saturation (g=0.19, P<0.001), and ferritin (g=0.22, P<0.001), and negatively correlated with age (g=-0.40, P<0.001) and lower in female patients (g=-0.56, P<0.001) in the Spearman correlation. The FEV1 was independently associated with serum iron (b=0.049, P=0.035) and transferrin saturation (b=0.049, P=0.035) after adjusting for age, sex, and body mass index in the multiple linear regression analyses.Conclusion: The serum iron and transferrin saturation levels were independently associated with FEV1 as a marker of chronic obstructive pulmonary disease severity.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Pauwels RA / 2001 / NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary / Am J Respir Crit Care Med 163:1256~1276
Kent BD / 2011 / Hypoxemia in patients with COPD: cause, effects, and disease progression / Int J Chron Obstruct Pulmon Dis 6:199~208
Armitage AE / 2011 / Hepcidin regulation by innate immune and infectious stimuli / Blood 118:4129~4139
Similowski T / 2006 / The potential impact of anaemia of chronic disease in COPD / Eur Respir J 27:390~396
Rogers J / 1994 / The role of cytokines in the regulation of ferritin expression / Adv Exp Med Biol 356:127~132
Kent BD / 2011 / Hypoxemia in patients with COPD: cause, effects, and disease progression / Int J Chron Obstruct Pulmon Dis 6:199~208
Armitage AE / 2011 / Hepcidin regulation by innate immune and infectious stimuli / Blood 118:4129~4139
Similowski T / 2006 / The potential impact of anaemia of chronic disease in COPD / Eur Respir J 27:390~396
Rogers J / 1994 / The role of cytokines in the regulation of ferritin expression / Adv Exp Med Biol 356:127~132
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