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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 356 - 365 (10page)
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초록· 키워드
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The aim of this study was to assess the relative urate-lowering efficacy and safety of febuxostat and allopurinol in hyperuricemic patients with or without gout. Methods. Randomized controlled trials (RCTs) examining the efficacy and safety of febuxostat compared to allopurinol or placebo in hyperuricemic patients with/without gout were included in this Bayesian network meta-analysis. Results. Eight RCTs including 4,099 patients met the inclusion criteria. The number of subjects achieving a serum urate (sUA) level ＜6.0 mg/dL was significantly higher in the febuxostat 120 mg and 80 mg groups than in the allopurinol (100 to 300 mg) group (odds ratio [OR] 7.17, 95% credible interval [CrI] 3.86 to 14.09; OR 3.49, 95% CrI 1.97 to 5.91, respectively). However, achievement of the target sUA level was comparable between febuxostat 40 mg and allopurinol. Ranking probability based on surface under the cumulative ranking curve (SUCRA) indicated that febuxostat 120 mg had the highest probability of being the best treatment for achieving the target sUA (SUCRA=0.9973), followed by febuxostat 80 mg (SUCRA=0.752), febuxostat 40 mg (SUCRA=0.4289), allopurinol (SUCRA=0.3217), and placebo (SUCRA=0). In contrast, no significant difference in safety based on the number of withdrawals due to adverse events was observed among the 5 interventions. Conclusion. Febuxostat 80 mg and 120 mg were more efficacious than allopurinol (100 to 300 mg), and febuxostat 40 mg and allopurinol were comparable in urate-lowering efficacy. The safety of febuxostat at all doses was comparable with that of allopurinol.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Wortmann RL. / 2002 / Gout and hyperuricemia / Curr Opin Rheumatol 14:281~286
Terkeltaub RA. / 2003 / Clinical practice. Gout / N Engl J Med 349:1647~1655
Zhang W. / 2006 / EULAR evidence based recommendations for gout. Part II : management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics(ESCISIT) / Ann Rheum Dis 65:1312~1324
Perez-Ruiz F. / 2007 / Lowering serum uric acid levels : what is the optimal target for improving clinical outcomes in gout? / Arthritis Rheum 57:1324~1328
Hande KR. / 1984 / Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency / Am J Med 76:47~56
Terkeltaub RA. / 2003 / Clinical practice. Gout / N Engl J Med 349:1647~1655
Zhang W. / 2006 / EULAR evidence based recommendations for gout. Part II : management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics(ESCISIT) / Ann Rheum Dis 65:1312~1324
Perez-Ruiz F. / 2007 / Lowering serum uric acid levels : what is the optimal target for improving clinical outcomes in gout? / Arthritis Rheum 57:1324~1328
Hande KR. / 1984 / Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency / Am J Med 76:47~56
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